ArticleMagnetic resonance in medicine2023
The future is 2D: spectral-temporal fitting of dynamic MRS data provides exponential gains in precision over conventional approaches.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Advanced methods in deuterium metabolic imaging.Magma (New York, N.Y.) · 2026Review
- Age dependency of neurometabolite TMagnetic resonance in medicine · 2025Article
- Stability of single-subject estimation of glutamate and GABA dynamics in concurrent fMRI-fMRS at 7 T.Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition · 2025Article
- Metabolite TMagnetic resonance in medicine · 2025Article
- Simultaneous Concentration and TNMR in biomedicine · 2025Article
- Investigating Neurometabolite Changes in Response to Median Nerve Stimulation.Brain and behavior · 2025Article
- Functional magnetic resonance spectroscopy of prolonged motor activation using conventional and spectral GLM analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Model-based frequency-and-phase correction ofMagnetic resonance in medicine · 2024Article
- Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation.Magnetic resonance in medicine · 2024Article
- Metabolite TbioRxiv : the preprint server for biology · 2024Article
- Universal dynamic fitting of magnetic resonance spectroscopy.Magnetic resonance in medicine · 2024Article
- Model-based frequency-and-phase correction ofbioRxiv : the preprint server for biology · 2024Article
- Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation.bioRxiv : the preprint server for biology · 2024Article
- The future is 2D: spectral-temporal fitting of dynamic MRS data provides exponential gains in precision over conventional approaches.Magnetic resonance in medicine · 2023Article
- A 7T interleaved fMRS and fMRI study on visual contrast dependency in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2023Article
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Abstract
purposeMany MRS paradigms produce 2D spectral-temporal datasets, including diffusion-weighted, functional, and hyperpolarized and enriched (carbon-13, deuterium) experiments. Conventionally, temporal parameters-such as T
methodsWe derived a Cramer Rao lower bound for the temporal parameters for both 1D and 2D approaches for 2 experiments: a multi-echo experiment designed to estimate metabolite T
resultsWhen peaks were spectrally distant, 2D fitting improved precision by approximately 20% relative to 1D fitting, regardless of the experiment and other parameter values. These gains increased exponentially as peaks drew closer. Dependence on temporal model parameters was weak to negligible.
conclusionOur results strongly support a 2D approach to MRS fitting where applicable, and particularly in nuclei such as hydrogen and deuterium, which exhibit substantial spectral overlap.
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