ArticlePlant biotechnology journal2023
A screening of inhibitors targeting the receptor kinase FERONIA reveals small molecules that enhance plant root immunity.
Article in Plant biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Plant immune inducers from fundamental research to applications: Past achievements, current challenges, and future perspectives.Plant communications · 2026Review
- Spatiotemporal reprogramming of auxin signaling and resistance outputs across model plants and solanaceae crops underFrontiers in plant science · 2026Review
- The HAESA family of receptor-like kinases: abscission pathways and emerging functions.Frontiers in plant science · 2026Review
- Unveiling FERONIA receptor kinase-mediated cellular mechanisms with a small-molecule inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- RALF33-FERONIA signaling orchestrates postwounding root-tip regeneration via TPR4-ERF115 dynamics.The Plant cell · 2025Article
- Unravelling the Molecular Dialogue of Beneficial Microbe-Plant Interactions.Plant, cell & environment · 2025Review
- RALF-FER, a master ligand‒receptor pair in plant health.Crop health · 2025Review
- Endophytic commensal bacteria capitalize on the AvrPto-FER pathway to enhance proliferation during early stages of pathogen invasion.The ISME journal · 2025Article
- Tackling vascular wilt disease: A signaling cascade to strengthen the plant cell wall.The Plant cell · 2024Article
- The FERONIA-RESPONSIVE TO DESICCATION 26 module regulates vascular immunity to Ralstonia solanacearum.The Plant cell · 2024Article
- A first-in-class dimethyl 2-acetamido terephthalate inhibitor targeting Conyza canadensis SHMT1 with a novel herbicidal mode-of-action.Journal of advanced research · 2024Article
- Large-scale analysis of the N-terminal regulatory elements of the kinase domain in plant Receptor-like kinase family.BMC plant biology · 2024Article
- Rice receptor kinase FLR7 regulates rhizosphere oxygen levels and enriches the dominant Anaeromyxobacter that improves submergence tolerance in rice.The ISME journal · 2024Article
- Structural and biochemical basis of Arabidopsis FERONIA receptor kinase-mediated early signaling initiation.Plant communications · 2023Article
- Plants and Small Molecules: An Up-and-Coming Synergy.Plants (Basel, Switzerland) · 2023Review
- Cell Wall Integrity Signaling in Fruit Ripening.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Receptor-like kinases (RLKs) constitute the largest receptor family involved in the regulation of plant immunity and growth, but small-molecule inhibitors that target RLKs to improve agronomic traits remain unexplored. The RLK member FERONIA (FER) negatively regulates plant resistance to certain soil-borne diseases that are difficult to control and cause huge losses in crop yields and economy. Here, we identified 33 highly effective FER kinase inhibitors from 1494 small molecules by monitoring FER autophosphorylation in vitro. Four representative inhibitors (reversine, cenisertib, staurosporine and lavendustin A) inhibited the kinase activity of FER and its homologues in several crops by targeting the conserved ATP pocket in the kinase structure. FER contributes to the physiological impact of representative inhibitors in plants. The treatment of roots with reversine, staurosporine and lavendustin A enhanced innate immunity in plant roots and thus alleviated soil-borne diseases in tobacco, tomato and rice without growth penalties. Consistently, RNA sequencing assays showed that lavendustin A and reversine exert profound impacts on immunity-related gene expression. Our results will set a new milestone in the development of the plant RLK kinase regulation theory and provide a novel strategy for the prevention and control of plant soil-borne diseases without growth penalties.
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