Evidence map›Paper›PMID 36121291›Full record

ArticleJournal of bacteriology2022

Chlamydia trachomatis RsbU Phosphatase Activity Is Inhibited by the Enolase Product, Phosphoenolpyruvate.

Christopher Rosario, Ming Tan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. The Regulatory Mechanisms of Treponema pallidum Enolase on Macrophages: From Enzymatic Activity to Signal Transduction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Article
  4. Tail-specific protease is an essentialInfection and immunity · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher RosarioDepartment of Microbiology and Molecular Genetics, University of California, Irvinegrid.266093.8grid.417319.9, California, USA.ORCID 0000-0002-3773-090X
Ming TanDepartment of Microbiology and Molecular Genetics, University of California, Irvinegrid.266093.8grid.417319.9, California, USA.ORCID 0000-0002-5361-583X
University of California, Irvine · US

Funding

The Regulation of gene expression in ChlamydiaR01AI044198 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI TAN, MING · 1999 to 2021
$7.1M
Mechanisms of temporal gene regulation in ChlamydiaR56AI044198 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI TAN, MING · 2010 to 2010
$383k
NIAID NIH HHS R01 AI044198NIAID NIH HHS R56 AI044198
6 · The paper itself

Abstract

The intracellular pathogen Chlamydia temporally regulates the expression of its genes, but the upstream signals that control transcription are not known. The best-studied regulatory pathway is a partner-switching mechanism that involves an anti-sigma factor, RsbW, which inhibits transcription by binding and sequestering the sigma subunit of RNA polymerase. RsbW is itself regulated by an anti-anti-sigma factor, RsbV, whose phosphorylation state is controlled by the phosphatase RsbU. In this study, we showed that Chlamydia trachomatis RsbU requires manganese or magnesium as a cofactor and dephosphorylates RsbV1 and RsbV2, which are the two chlamydial paralogs of RsbV. The gene for RsbU is adjacent to the enolase gene in a number of Chlamydia genomes, and we showed that

Indexed as

Chlamydia trachomatisSigma FactorBacterial ProteinsDNA-Directed RNA PolymerasesGene Expression Regulation, BacterialGlucoseMagnesiumManganesePhosphoenolpyruvatePhosphopyruvate HydratasePhosphoric Monoester HydrolasesBacterial ProteinsDNA-Directed RNA PolymerasesGlucoseMagnesiumManganesePhosphoenolpyruvatePhosphopyruvate HydratasePhosphoric Monoester HydrolasesSigma Factorgene regulationglucose metabolismglycolytic pathwaysignaling pathway

Identifiers

PMID36121291
PMCPMC9578391
OpenAlexW4296322850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.