ArticleAngewandte Chemie (International ed. in English)2022
Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
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- Conversion of pyridoxal to pyridoxamine with NHThe FEBS journal · 2025Article
- Carbon fluxes rewiring in engineered E. coli via reverse tricarboxylic acid cycle pathway under chemolithotrophic condition.Journal of biological engineering · 2025Article
- A New Mechanism for Formation of Glycine from Glyoxylic Acid: the Aza-Cannizzaro Reaction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes.Accounts of chemical research · 2024Article
- Ferredoxin reduction by hydrogen with iron functions as an evolutionary precursor of flavin-based electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Prebiotic Synthesis of Aspartate Using Life's Metabolism as a Guide.Life (Basel, Switzerland) · 2023Article
- Biophysical Interactions Underpin the Emergence of Information in the Genetic Code.Life (Basel, Switzerland) · 2023Article
- Quantification of the hydride donor abilities of NADH, NADPH, and BHOrganic & biomolecular chemistry · 2022Article
- Quantifying Reductive Amination in Nonenzymatic Amino Acid Synthesis.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amino acid biosynthesis initiates with the reductive amination of α-ketoglutarate with ammonia to produce glutamate. However, the other α-keto acids derived from the glyoxylate and Krebs cycles are converted into amino acids by transamination, rather than by reductive amination. Why is only one amino acid synthesized by reductive amination and not the others? To explore this question, we quantified the inherent reactivities of keto acids in nonenzymatic reduction and reductive amination by using BH
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