Evidence map›Paper›PMID 36121151›Full record

ArticlemBio2022

Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in

Sean A Bergin, Fang Zhao, Adam P Ryan, Carolin A Müller, Conrad A Nieduszynski, Bing Zhai, Thierry Rolling, Tobias M Hohl, Florent Morio, Jillian Scully and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Small pangenome ofmBio · 2025
    Article
  7. Osh2 mediatesAntimicrobial agents and chemotherapy · 2025
    Article
  8. International journal of systematic and evolutionary microbiology · 2025
    Article
  9. Review
  10. Transcriptomic and proteomic ramifications of segmental amplification inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Draft genome sequence of a non-human primate-derived isolate ofMicrobiology resource announcements · 2025
    Article
  12. Review
  13. Article
  14. Emerging fluconazole-resistantFrontiers in microbiology · 2025
    Article
  15. Threats from theMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Sean A Bergin *School of Biomolecular and Biomedical Science, Conway Institute, University College Dublingrid.7886.1, Belfield, Dublin, Ireland.
Fang Zhao *School of Biomolecular and Biomedical Science, Conway Institute, University College Dublingrid.7886.1, Belfield, Dublin, Ireland.
Adam P RyanSchool of Biomolecular and Biomedical Science, Conway Institute, University College Dublingrid.7886.1, Belfield, Dublin, Ireland.
Carolin A MüllerSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Conrad A NieduszynskiEarlham Institute, Norwich, United Kingdom.
Bing ZhaiInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Centergrid.51462.34, New York, New York, USA.
Thierry RollingInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Centergrid.51462.34, New York, New York, USA.
Tobias M HohlInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Centergrid.51462.34, New York, New York, USA.ORCID 0000-0002-9097-5412
Florent MorioNantes Université, CHU de Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, Nantes, France.
Jillian ScullySchool of Biomolecular and Biomedical Science, Conway Institute, University College Dublingrid.7886.1, Belfield, Dublin, Ireland.
Kenneth H WolfeSchool of Medicine, Conway Institute, University College Dublingrid.7886.1, Belfield, Dublin, Ireland.ORCID 0000-0003-4992-4979
Geraldine ButlerSchool of Biomolecular and Biomedical Science, Conway Institute, University College Dublingrid.7886.1, Belfield, Dublin, Ireland.ORCID 0000-0002-1770-5301
University College Dublin · IEMemorial Sloan Kettering Cancer Center · USCentre Hospitalier Universitaire de Nantes · FRUniversity of East Anglia · GBUniversity of Oxford · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
INITIATION OF THE IMMUNE RESPONSE TO ASPERGILLUS FUMIGATUSR01AI093808 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2011 to 2020
$4.9M
The mycobiota, bone marrow transplantation, and clinical outcomesR21AI156157 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HOHL, TOBIAS M · 2021 to 2022
$487k
Biotechnology and Biological Sciences Research Council BB/CCG1720/1NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI093808NIAID NIH HHS R21 AI156157
6 · The paper itself

Abstract

We analyzed the genomes of 170 C. parapsilosis isolates and identified multiple copy number variations (CNVs). We identified two genes,

Indexed as

Candida parapsilosisDrug Resistance, FungalAntifungal AgentsArsenatesCandidiasisDNA Copy Number VariationsGene AmplificationPhosphatidylcholinesPhosphorylcholinePhylogenySaccharomyces cerevisiaeAntifungal AgentsArsenatesmiltefosinePhosphatidylcholinesPhosphorylcholineCandidacopy number variationdrug resistance evolutiongenomics

Identifiers

PMID36121151
PMCPMC9600344
OpenAlexW4296328295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.