Evidence map›Paper›PMID 36121132›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Exploring the difference in the mechanics of vascular smooth muscle cells from wild-type and apolipoprotein-E knockout mice.

Alex P Rickel, Hanna J Sanyour, Courtney Kinser, Nisha Khatiwada, Hayley Vogel, Zhongkui Hong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alex P RickelBiomedical Engineering Department, University of South Dakota, Sioux Falls, South Dakota.
Hanna J SanyourBiomedical Engineering Department, University of South Dakota, Sioux Falls, South Dakota.
Courtney KinserBiomedical Engineering Department, University of South Dakota, Sioux Falls, South Dakota.
Nisha KhatiwadaBiomedical Engineering Department, University of South Dakota, Sioux Falls, South Dakota.
Hayley VogelBiomedical Engineering Department, University of South Dakota, Sioux Falls, South Dakota.
Zhongkui HongBiomedical Engineering Department, University of South Dakota, Sioux Falls, South Dakota.ORCID 0000-0003-1745-6488
University of South Dakota · USTexas Tech University · US

Funding

Mechanical Response and Cytoskeletal Rearrangement Following Interrupted Cholesterol Metabolism in Vascular Smooth Muscle CellR15HL147214 · NHLBI · UNIVERSITY OF SOUTH DAKOTA · PI HONG, ZHONGKUI · 2020 to 2020
$429k
NHLBI NIH HHS R15 HL147214
6 · The paper itself

Abstract

Atherosclerosis-related cardiovascular diseases are a leading cause of mortality worldwide. Vascular smooth muscle cells (VSMCs) comprise the medial layer of the arterial wall and undergo phenotypic switching during atherosclerosis to a synthetic phenotype capable of proliferation and migration. The surrounding environment undergoes alterations in extracellular matrix (ECM) stiffness and composition and an increase in cholesterol content. Using an atherosclerotic murine model, we analyzed how the mechanics of VSMCs isolated from Western diet-fed apolipoprotein-E knockout (

Indexed as

AtherosclerosisMuscle, Smooth, VascularAnimalsApolipoproteins ECadherinsCell ProliferationCells, CulturedCholesterolGelsMiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleApoe protein, mouseApolipoproteins ECadherinsCholesterolGelsapolipoprotein-E knockoutatomic force microscopycell adhesioncell mechanicsvascular smooth muscle cells

Identifiers

PMID36121132
PMCPMC9602701
OpenAlexW4296327325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.