Evidence map›Paper›PMID 36121094›Full record

ArticleCurrent stem cell research & therapy2023

HOXA10 Expressing UCMSCs Transplantation Improved Endometrial Receptivity on Endometrial Injury.

Meixian Wu, Yuanyuan Li, Yiwei Wang, Yifan Li, Jinghui Li, Jing Xie, Shuang Zhao, Lihua Sun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current stem cell research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Meixian WuInstitute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Cellular Stemness & Cell Fate Editing, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China.
Yuanyuan LiInstitute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Cellular Stemness & Cell Fate Editing, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China.
Yiwei WangInstitute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Cellular Stemness & Cell Fate Editing, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China.
Yifan LiInstitute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Cellular Stemness & Cell Fate Editing, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China.
Jinghui LiInstitute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Cellular Stemness & Cell Fate Editing, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China.
Jing XieInstitute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Cellular Stemness & Cell Fate Editing, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R. China.
Shuang ZhaoDepartment of Reproductive Medicine Center, Shanghai East Hospital, Tongji University, Shanghai 200123, P.R. China.
Lihua SunDepartment of Reproductive Medicine Center, Shanghai East Hospital, Tongji University, Shanghai 200123, P.R. China.
Shanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometrial injury is considered the major cause of female infertility. Traditional therapies such as estrogen substitution therapy are not satisfactory due to individual variation in response to treatment, thereby warranting the use of alternative strategies such as stem cell therapy. Transplantation of stem cells, such as umbilical cord mesenchymal stem cells (UCMSCs), has been shown to improve endometrial healing. However, due to the effect of the intrauterine environment, the therapeutic effect of UCMSCs is limited, and its efficacy is unstable. HOXA10, encoded by the HOXA10 gene, plays an important role in endometrium morphology maintenance, proliferation, differentiation, and embryo implantation. Moreover, UCMSCs do not show HOXA10 expression.

objectiveOur study aimed to evaluate the therapeutic effects of HOXA10-transfected UCMSCs on endometrial injury repair in vivo.

methodsFirst, we established T10-UCMSCs (UCMSCs transfected with HOXA10) for transplantation. To establish the endometrial injury model, we injected 95% ethanol into the uterine cavity and transplanted T10-UCMSCs into the uterine cavity from the cornua uteri. Fourteen days later, uteri were collected for histological and biochemical analysis of endometrial growth and receptivity.

resultsOur results showed the endometrial receptivity was better in T10-UCMSCs group than in UCMSCs group, suggesting that HOXA10 could enhance the repairing ability of UCMSCs in the endometrium injury repair. More importantly, the fertility test showed that more embryos were implanted in the T10- UCMSCs group.

conclusionOur results suggest that UCMSCs with HOXA10 expression could improve the therapeutic effects on endometrial injury repairing.

Indexed as

Embryo ImplantationEndometriumCell DifferentiationFemaleHomeobox A10 ProteinsHumansUmbilical CordHomeobox A10 ProteinsHOXA10 protein, humanembryo implantationendometrial injuryendometrial receptivityHOXA10lentivirusUCMSCs

Identifiers

PMID36121094
PMCPMC10278240
OpenAlexW4296329501

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.