Evidence map›Paper›PMID 36120960›Full record

Trial reportRenal failure2022

Urinary NGAL, IGFBP-7, and TIMP-2: novel biomarkers to predict contrast medium-induced acute kidney injury in children.

Qianliang Sun, Zhijuan Kang, Zhihui Li, Mai Xun

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07294911 (Predictors of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndrome), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07294911 completednot on this mapstarted 2024, after this paper: background citation

Predictors of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndrome

TypeobservationalSponsorKaraganda Medical UniversityRan2024 to 2025Enrolled88ConditionsAcute Coronary Syndrome, Contrast-Induced Acute Kidney InjuryArmsObservational data collection
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury After Massive Burns.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qianliang SunCollege of Pediatrics, University of South China/Children's Hospital of Hunan Province, Changsha, P.R. China.
Zhijuan KangCollege of Pediatrics, University of South China/Children's Hospital of Hunan Province, Changsha, P.R. China.
Zhihui LiCollege of Pediatrics, University of South China/Children's Hospital of Hunan Province, Changsha, P.R. China.
Mai XunCollege of Pediatrics, University of South China/Children's Hospital of Hunan Province, Changsha, P.R. China.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum creatinine (SCr) is unreliable in detecting acute changes in kidney function. Early recognition of contrast-induced acute kidney injury (CI-AKI) can provide better opportunities for preventive interventions. Therefore, the purpose of this study is to examine the value of the combined detection of urinary neutrophil gelatinase-associated lipocalin (NGAL), insulin-like growth factor binding protein-7 (IGFBP-7), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the early diagnosis of children with CI-AKI.

methodsA prospective, single-center clinical trial was performed and included 172 children aged 0-18 years. The dynamic changes of urinary NGAL, IGFBP-7, and TIMP-2 levels in children with intravascular injection of contrast medium were investigated to determine whether they can diagnose CI-AKI early.

resultsCI-AKI occurred in 20 of 137 enrolled patients, and the incidence was 14.59%. In the CI-AKI group, urinary levels of NGAL, IGFBP-7, TIMP-2, and [IGFBP-7]*[TIMP-2] were significantly increased 2 h after angiography and remained at high levels at 6 h. Using a cutoff value of 36.274 ng/mL, the specificity was 70.0%, and the sensitivity was 68.4% for the prediction of CI-AKI, which was excellent for urinary NGAL. When both urinary IGFBP-7 and TIMP-2 were used together, urinary [IGFBP-7]*[TIMP-2] at 0.417(ng/mL)

conclusionsNGAL, IGFBP-7, and TIMP-2 concentrations in the urine of children after receiving injections of contrast medium increased faster than SCr and had good clinical value for the early diagnosis of CI-AKI in children. The combination of IGFBP-7 and TIMP-2 was better than either analyte alone.

Indexed as

Acute Kidney InjuryTissue Inhibitor of Metalloproteinase-2BiomarkersChildCreatinineHumansInsulin-Like Growth Factor Binding ProteinsLipocalin-2Prospective StudiesBiomarkersCreatinineinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsLipocalin-2Tissue Inhibitor of Metalloproteinase-2Acute kidney injurybiomarkerschildcontrast mediumurinary

Identifiers

PMID36120960
PMCPMC9518296
OpenAlexW4296322653

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.