ArticlePlant, cell & environment2023
Acquisition of hypoxia inducibility by oxygen sensing N-terminal cysteine oxidase in spermatophytes.
Article in Plant, cell & environment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Rorippa islandica: a genetically accessible dicot model system to study flooding tolerance.Plant physiology · 2026Article
- Progressive oxygenation of developing leaves directs morphogenesis.Science advances · 2026Article
- Hypoxic and Fe-Responses are Regulated by the ERFVII Factors and the PCO Branch of the N-Degron Pathway According to Iron Availability.Plant, cell & environment · 2026Article
- HNature · 2026Article
- Insights into enhanced, divergent, and additive responses to single and combined hypoxia-salt stress.BMC plant biology · 2026Article
- A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An overview of low-oxygen sensing and flooding responses of tomato.Journal of experimental botany · 2025Review
- ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia.Molecular plant · 2025Article
- Oxygen sensing and plant adaptation to flooding in a changing climate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Destined for destruction: The role of methionine aminopeptidases and plant cysteine oxidases in N-degron formation.Plant physiology · 2024Review
- Geography, altitude, agriculture, and hypoxia.Plant physiology · 2024Review
- Transcriptomics of long-term, low oxygen storage coupled with ethylene signaling interference suggests neofunctionalization of hypoxia response pathways in apple (Plant direct · 2024Article
- Post-Translational Modifications to Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction.International journal of molecular sciences · 2024Review
- BIG enhances Arg/N-degron pathway-mediated protein degradation to regulate Arabidopsis hypoxia responses and suberin deposition.The Plant cell · 2024Article
- ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana.Nature communications · 2023Article
- Genome-Wide Identification and Analysis of the Plant Cysteine Oxidase (PCO) Gene Family inInternational journal of molecular sciences · 2023Article
- Plant responses to limited aeration: Advances and future challenges.Plant direct · 2023Article
- Acquisition of hypoxia inducibility by oxygen sensing N-terminal cysteine oxidase in spermatophytes.Plant, cell & environment · 2023Article
- Plant Cysteine Oxidase Oxygen-Sensing Function Is Conserved in Early Land Plants and Algae.ACS bio & med chem Au · 2022Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-terminal cysteine oxidases (NCOs) use molecular oxygen to oxidise the amino-terminal cysteine of specific proteins, thereby initiating the proteolytic N-degron pathway. To expand the characterisation of the plant family of NCOs (plant cysteine oxidases [PCOs]), we performed a phylogenetic analysis across different taxa in terms of sequence similarity and transcriptional regulation. Based on this survey, we propose a distinction of PCOs into two main groups. A-type PCOs are conserved across all plant species and are generally unaffected at the messenger RNA level by oxygen availability. Instead, B-type PCOs appeared in spermatophytes to acquire transcriptional regulation in response to hypoxia. The inactivation of two A-type PCOs in Arabidopsis thaliana, PCO4 and PCO5, is sufficient to activate the anaerobic response in young seedlings, whereas the additional removal of B-type PCOs leads to a stronger induction of anaerobic genes and impairs plant growth and development. Our results show that both PCO types are required to regulate the anaerobic response in angiosperms. Therefore, while it is possible to distinguish two clades within the PCO family, we conclude that they all contribute to restrain the anaerobic transcriptional programme in normoxic conditions and together generate a molecular switch to toggle the hypoxic response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.