Evidence map›Paper›PMID 36120576›Full record

ArticleFrontiers in cell and developmental biology2022

Histamine activates an intracellular Ca

Roberto Berra-Romani, Ajelet Vargaz-Guadarrama, Josué Sánchez-Gómez, Nayeli Coyotl-Santiago, Efraín Hernández-Arambide, José Everardo Avelino-Cruz, Mario García-Carrasco, Monica Savio, Giorgia Pellavio, Umberto Laforenza and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. The CaInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Histamine-induced cytosolic calcium mobilization in human bronchial smooth muscle cells.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025
    Article
  6. Article
  7. Neuroplasticity in the transition from acute to chronic pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  8. Article
  9. Store-Operated CaContact (Thousand Oaks (Ventura County, Calif.))
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Roberto Berra-RomaniDepartment of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Ajelet Vargaz-GuadarramaDepartment of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Josué Sánchez-GómezDepartment of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Nayeli Coyotl-SantiagoDepartment of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Efraín Hernández-ArambideDepartment of Biomedicine, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.
José Everardo Avelino-CruzLaboratory of Molecular Cardiology, Institute of Physiology, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Mario García-CarrascoDepartment of Immunology, School of Medicine, Benemérita Universidad Autónoma de Puebla, Puebla, México.
Monica SavioDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Giorgia PellavioDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Umberto LaforenzaDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.
Alfredo Lagunas-MartínezDirection of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Morelos, México.
Francesco MocciaLaboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.
Benemérita Universidad Autónoma de Puebla · MXUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma. In addition to stimulating airway smooth muscle cell constriction and hyperplasia, histamine promotes pulmonary remodeling by inducing fibroblast proliferation, contraction, and migration. It has long been known that histamine receptor 1 (H1R) mediates the effects of histamine on human pulmonary fibroblasts through an increase in intracellular Ca

Indexed as

Ca2+ oscillationshistamineInsP3 receptorsintracellular Ca2+lung fibroblastsstore-operated Ca2+ entryWI-38

Identifiers

PMID36120576
PMCPMC9478493
OpenAlexW4294204207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.