Evidence map›Paper›PMID 36120560›Full record

ArticleFrontiers in cell and developmental biology2022

Effects of mutant lamins on nucleo-cytoskeletal coupling in

Nicholas M Shaw, Jose L Rios-Monterrosa, Gregory R Fedorchak, Margaret R Ketterer, Gary S Coombs, Jan Lammerding, Lori L Wallrath

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. An Unbiased Drug Screen in a Drosophila Model ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Cells · 2025
    Review
  8. Article
  9. A genetic variant inScience advances · 2025
    Article
  10. Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025
    Review
  11. The Influence of a Genetic Variant inInternational journal of molecular sciences · 2024
    Article
  12. Article
  13. Lamins as structural nuclear elements through evolution.Current opinion in cell biology · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nicholas M ShawDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Jose L Rios-MonterrosaDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Gregory R FedorchakThe Nancy E. and Peter C. Meinig School of Biomedical Engineering, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, United States.
Margaret R KettererDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Gary S CoombsBiology Department, Waldorf University, Forest City, IA, United States.
Jan LammerdingThe Nancy E. and Peter C. Meinig School of Biomedical Engineering, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, United States.
Lori L WallrathDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
University of Iowa · USCornell University · USWaldorf College · US

Funding

Nuclear mechanics and mechanotransduction in muscular laminopathiesR01HL082792 · NHLBI · CORNELL UNIVERSITY · PI LAMMERDING, JAN · 2007 to 2023
$4.8M
Smad signaling in skeletal muscle laminopathiesR21AR075193 · NIAMS · UNIVERSITY OF IOWA · PI WALLRATH, LORI L · 2020 to 2021
$369k
NHLBI NIH HHS R01 HL082792NIAMS NIH HHS R21 AR075193
6 · The paper itself

Abstract

The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear membrane. Lamins play a myriad of roles, including maintenance of nuclear shape and stability, mediation of nuclear mechanoresponses, and nucleo-cytoskeletal coupling. Herein, we investigate how disease-causing mutant lamins alter myonuclear properties in response to mechanical force. This was accomplished

Indexed as

DrosophilalaminsLINC complexmicrotubulesmusclemuscular dystrophiesmyonuclei

Identifiers

PMID36120560
PMCPMC9471154
OpenAlexW4293728177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.