Evidence map›Paper›PMID 36120472›Full record

ReviewFrontiers in endocrinology2022

Anti-Mullerian Hormone (AMH) and adenomyosis: Mini-review of literature of the last 5 years.

Ferdinando Antonio Gulino, Valentina Dilisi, Stella Capriglione, Francesco Cannone, Francesco Catania, Francesco Giuseppe Martire, Attilio Tuscano, Marianna Gulisano, Valentina D'Urso, Alessandra Di Stefano and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Endometriosis and Nutrition: Therapeutic Perspectives.Journal of clinical medicine · 2025
    Review
  5. Article
  6. Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up.Current issues in molecular biology · 2025
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Ferdinando Antonio GulinoDepartment of Obstetrics and Gynecology, Azienda di Rilievo Nazionale e Alta Specializzazione (ARNAS) Garibaldi, Catania, Italy.
Valentina DilisiDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
Stella CapriglioneDepartment of Obstetrics and Gynecology, Ospedale "Santa Maria Alla Gruccia", Montevarchi, Italy.
Francesco CannoneDepartment of Obstetrics and Gynecology, Azienda di Rilievo Nazionale e Alta Specializzazione (ARNAS) Garibaldi, Catania, Italy.
Francesco CataniaDepartment of Obstetrics and Gynecology, Ospedale "Santa Maria Alla Gruccia", Montevarchi, Italy.
Francesco Giuseppe MartireGynecological Unit, Department of Surgical Sciences, University of Rome "Tor Vergata", Roma, Italy.
Attilio TuscanoDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
Marianna GulisanoDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
Valentina D'UrsoDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
Alessandra Di StefanoDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
Monia Caterina CiminoDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
Maurizio FilippiniDepartment of Obstetrics and Gynaecology, Ospedale di Stato, Cailungo, San Marino.
Silvia LatellaDepartment of Obstetrics and Gynaecology, Ospedale di Stato, Cailungo, San Marino.
Margaret SammariniDepartment of Obstetrics and Gynaecology, Ospedale di Stato, Cailungo, San Marino.
Giulia MusmeciDepartment of Hospital Pharmacy, San'Elia Hospital, Caltanissetta, Italy.
Marco Antonio PalumboDepartment of Medical Surgical Specialties, Gynecology and Obstetrics Section, University of Catania, Catania, Italy.
University of Catania · ITOspedale di Stato della Repubblica di San Marino · SMAzienda di Rilievo Nazionale ed Alta Specializzazione · ITOspedale Santa Maria · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Adenomyosis is a form of endometriosis characterized by the presence of endometrial tissue in the myometrium. The correlation between anti-Mullerian hormone (AMH) expression and adenomyosis is unclear. Few studies investigated this possible correlation with promising results. The aim of this mini-review is to illustrate the potential prognostic and therapeutic role of AMH in adenomyosis. Materials and methods: A study protocol was completed conforming to the Preferred Reporting Items for Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews. We performed an electronic databases search from each database's inception from August 2017 to August 2022 for full-text articles and published abstracts. For database searches, the following main keywords were the following text words: "adenomyosis" or "uterine endometriosis" [Mesh] AND "AMH" or "anti-mullerian hormone". Results: From the literature search, 8 abstracts of studies were retrieved and independently screened for inclusion by three authors. It was found that the most common therapeutic strategies (such as adenomyomectomy and high-intensity focused ultrasound (HIFU) do not alter AMH levels. Moreover, a higher expression of the AMH receptor II was observed in adenomyotic tissue, hence a possible therapeutic use of AMH was hypothesized. Conclusion: The available evidence shows an unclear relationship between adenomyosis and AMH. Probably, women with adenomyosis have lower levels of AMH and the surgical treatment (adenomyomectomy, HIFU) does not alter this characteristic, therefore in all of them, ovarian function is not influenced.

Indexed as

AdenomyosisEndometriosisPeptide HormonesAnti-Mullerian HormoneFemaleHumansPrognosisAnti-Mullerian HormonePeptide Hormonesadenomyomectomyadenomyosisamhfertilityhifu (high intensity focus ultrasound)

Identifiers

PMID36120472
PMCPMC9471373
OpenAlexW4293767701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.