Evidence map›Paper›PMID 36120446›Full record

ArticleFrontiers in endocrinology2022

Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation.

Iryna Khrystoforova, Chen Shochat-Carvalho, Ram Harari, Katrin Henke, Katherine Woronowicz, Matthew P Harris, David Karasik

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. CRISPR/Cas9-Mediated Disruption ofInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iryna KhrystoforovaAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Chen Shochat-CarvalhoAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Ram HarariAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Katrin HenkeDepartment of Orthopedics, Emory University, Atlanta, GA, United States.
Katherine WoronowiczDepartment of Orthopaedics, Boston Children's Hospital, Boston, MA, United States.
Matthew P HarrisDepartment of Orthopaedics, Boston Children's Hospital, Boston, MA, United States.
David KarasikAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-density Lipoprotein Receptor-related Protein 5 (

Indexed as

Low Density Lipoprotein Receptor-Related Protein-5OsteoclastsAnimalsHumansLigandsMammalsMatrix Metalloproteinase 9Tartrate-Resistant Acid PhosphataseZebrafishLigandsLow Density Lipoprotein Receptor-Related Protein-5LRP5 protein, humanMatrix Metalloproteinase 9Tartrate-Resistant Acid Phosphatasebonelrp5osteoclastosteoporosiszebrafish

Identifiers

PMID36120446
PMCPMC9478031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.