ArticleFrontiers in endocrinology2022
Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance.
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Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Spatially convergent functional MRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain ageing.Brain communications · 2026Article
- Metabolic and Inflammatory Stimuli Impact Vascular Circulation and Cell Proliferation Processes in the Amygdala.Genes, brain, and behavior · 2025Article
- Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.Science advances · 2024Article
- 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.Science advances · 2024Article
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Authors and funding
26 authors at 4 institutions in 2 countries.
Zhou PeiDepartment of Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University, Shanghai, China.
Yang HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Jonathan C BeanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Hailan LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Meng YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Kaifan YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Ilirjana HyseniChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Xing CaiChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Hesong LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Na QuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Longlong TuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Kristine M CondeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Mengjie WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Yongxiang LiChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Na YinChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Nan ZhangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Junying HanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Camille Hs PottsChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Nikolas A ScarcelliChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Zili YanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Pingwen XuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, United States.
Qi WuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Yanlin HePennington Biomedical Research Center, Brain Glycemic and Metabolism Control Department, Louisiana State University, Baton Rouge, LA, United States.
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States.
Children's Nutrition Research Center at Baylor College of Medicine · USBaylor College of Medicine · USLouisiana State University · USUniversity of Illinois Chicago · US
Funding
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Jacqueline M Stephens · 2020 to 2026
$18.4MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SREEKUMAR, ARUN · 2018 to 2022
$7.9MTestosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasisR01DK123098 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2020 to 2024
$2.5MGABA neurons in the ventromedial hypothalamus contribute to the counterregulatory responseR01DK129548 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Yanlin He · 2022 to 2026
$2.1MHypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0M5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKER01DK120858 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TONG, QINGCHUN, XU, YONG · 2020 to 2023
$1.9MNeurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8MA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR01DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2017 to 2021
$1.8MBrain Estrogen Regulates Energy and Glucose BalanceR01DK125480 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2020 to 2023
$1.6MDiverse control of motivational and consummatory feeding by a hindbrain dopaminergic neural circuitR01DK131596 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2022 to 2024
$1.1MMedial amygdala ERα neurocircuits in the regulation of physical activityR00DK107008 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2018 to 2020
$743kA TAP63 TRANSCRIPTIONAL AXIS CONTRIBUTES TO THE SEXUAL DIMORPHISM IN POMC NEURON FUNCTIONS AND ENERGY HOMEOSTASISK01DK119471 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WANG, CHUNMEI · 2019 to 2021
$391kNIDDK NIH HHS K01 DK119471NIDDK NIH HHS P01 DK113954NIDDK NIH HHS R00 DK107008NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R01 DK120858NIDDK NIH HHS R01 DK123098NIDDK NIH HHS R01 DK125480NIDDK NIH HHS R01 DK129548NIDDK NIH HHS R01 DK131596NIDDK NIH HHS R56 DK109194NIGMS NIH HHS P20 GM135002
Abstract
Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are not well understood. The α5 subunit of GABA
Indexed as
GlucosePro-OpiomelanocortinAnimalsBody WeightFemaleMaleMiceMice, TransgenicNeuronsReceptors, GABA-AGabra5 protein, mouseGlucosePro-OpiomelanocortinReceptors, GABA-AGABAA receptorGABAergic inputglucose tolerancePOMC neuronssex differences
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.