Evidence map›Paper›PMID 36120349›Full record

ArticleFrontiers in pharmacology2022

Empagliflozin induces apoptotic-signaling pathway in embryonic vasculature:

Saeedeh Mosallanejad, Mehdi Mahmoodi, Hadi Tavakkoli, Ahmad Khosravi, Ehsan Salarkia, Alireza Keyhani, Shahriar Dabiri, Mohammad Hossein Gozashti, Abbas Pardakhty, Hadi Khodabandehloo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. An inclusive assessment of apoptosis mechanisms inCurrent research in parasitology & vector-borne diseases · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Saeedeh MosallanejadDepartment of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Mehdi MahmoodiDepartment of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Hadi TavakkoliDepartment of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Ahmad KhosraviLeishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Ehsan SalarkiaLeishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Alireza KeyhaniLeishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Shahriar DabiriAfzalipour School of Medicine, Pathology and Stem Cell Research Center, Kerman University of Medical Science, Kerman, Iran.
Mohammad Hossein GozashtiEndocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Abbas PardakhtyPharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Hadi KhodabandehlooDepartment of Clinical Biochemistry, School of Medicine Zanjan University of Medical Sciences, Zanjan, Iran.
Hossein PourghadamyariDepartment of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Kerman University of Medical Sciences · IRShahid Bahonar University of Kerman · IRZanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present investigation was conducted to evaluate the vascular-toxicity of empagliflozin (EMP) in embryonic vasculature. Firstly, the vascular-toxicity of the drug as well as its interaction with apoptotic regulator proteins was predicted

Indexed as

apoptosisempagliflozinimmunohistochemistrymolecular dynamicsyolk sac membrane

Identifiers

PMID36120349
PMCPMC9474685
OpenAlexW4294343651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.