Evidence map›Paper›PMID 36120275›Full record

ArticleCureus2022

Nutritional Status in a Sample of Patients With β-Thalassemia Major.

Irene Lidoriki, George Stavrou, Dimitrios Schizas, Maximos Frountzas, Lampros Fotis, Alkistis Kapelouzou, Smaro Kokkota, Barbara Fyntanidou, Katerina Kotzampassi

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In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07204015 (Body Composition in Pediatric Patients With Thalassemia Major Attending Assiut University Children's Hospital), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07204015 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Body Composition in Pediatric Patients With Thalassemia Major Attending Assiut University Children's Hospital

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled115ConditionsBody Composition in Thalassemia Major
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. An In-Depth Analysis of Variable Dynamics Influencing Bone Mineral Density in Transfusion-Dependent Thalassemia Patients.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Irene LidorikiFirst Department of Surgery, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC.
George StavrouDepartment of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Dimitrios SchizasFirst Department of Surgery, Laikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, GRC.
Maximos FrountzasFirst Propaedeutic Department of Surgery, "Hippocration" General Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Lampros FotisThird Department of Paediatrics, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Alkistis KapelouzouClinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, Athens, GRC.
Smaro KokkotaDepartment of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Barbara FyntanidouDepartment of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Katerina KotzampassiDepartment of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients suffering from thalassemia have decreased levels of lean body mass and an increased nutritional risk. To assess the body composition and vitamin D levels of thalassemic patients in relation to nutritional risk.

methodsA total of 67 consecutive adult patients who were diagnosed with thalassemia major and followed a regular blood transfusion scheme were included in this study. Demographic and clinical data were collected for each participant. Blood samples were collected to assess 25-hydroxy-vitamin D (25-OH-D) levels. The assessment of patients' nutritional risk was based on the Malnutrition Universal Screening Tool. Body composition assessment was based on bioelectrical impedance analysis (BIA).

resultsEleven patients (16.4%) and five patients (7.5%) were at moderate and high risk for malnutrition, respectively. Moreover, 86.6% of patients had a low fat-free mass index (FFMI) and 74.6% of patients had a high-fat mass (FM) index. The prevalence of sarcopenic obesity and 25-OH-D deficiency was 64.2% and 92.2%, respectively. Medium and high-risk patients had significantly lower BMI (18.81 ± 1.29 vs 23.90 ± 2.65 kg/m

conclusionsAdult patients with β-thalassemia major had low levels of vitamin D and altered body composition, presenting with increased adiposity, low levels of lean body mass, and high rates of sarcopenic obesity. Timely detection of patients at risk could lead to the prioritization of patients who could benefit from nutritional interventions.

Indexed as

body compositionnutritional assessmentscreening of nutritional statuss:malnutritionvitamin dβ-thalassemia

Identifiers

PMID36120275
PMCPMC9468758

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Registered trials

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