Evidence map›Paper›PMID 36120121›Full record

ArticleChinese herbal medicines2022

He-Wei Granule enhances anti-tumor activity of cyclophosphamide by changing tumor microenvironment.

Jianxiu Zhai, Zehai Song, Hang Chang, Yuwei Wang, Na Han, Zhihui Liu, Jun Yin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese herbal medicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jianxiu ZhaiKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zehai SongKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Hang ChangKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yuwei WangKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Na HanKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhihui LiuKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Jun YinKey Laboratory of Northeast Plant Materials, Department of Pharmacognosy and Utilization, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: He-Wei Granule (HWKL) is a modern product derived from the modified formulation of traditional Chinese medicine Banxia Xiexin Decoction (BXD), which remarkedly enhanced the anti-proliferation activity of cyclophosphamide (CTX) on HepG2 and SGC-7901 cell lines Methods: The CTX-toxic-reducing efficacy of HWKL was evaluated by hematology indexes, organ indexes and marrow DNA detection. To investigate the underlying mechanisms, histopathology test, immunohistochemistry test and TUNEL staining were conducted. The efficacy of HWKL on the micro-vessel density (MVD) in tumor tissue was also evaluated by measuring CD34 level. Results: High dose HWKL (6.75 g/kg) markedly attenuated CTX-induced hepatotoxicity and myelosuppression while significantly enhanced CTX anticancer efficacy Conclusion: It can be concluded that high-dose HWKL enhanced CTX efficacy by promoting apoptosis, inhibiting autophagy and angiogenesis in tumor tissue while significantly alleviated CTX-induced toxicity, and could be applied along with CTX in clinical treatment as a supplement agent.

Indexed as

cyclophosphamideH22 carcinomaHe-Wei Granulesynergistic effecttoxicity

Identifiers

PMID36120121
PMCPMC9476702
OpenAlexW3205683784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.