ArticleACS omega2022
Computational Insights into the Regeneration of Ovothiol and Ergothioneine and Their Selenium Analogues by Glutathione.
Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Natural Histidine Derivatives-From Basic Research to Potential Applications in Cosmetics and Nutricosmetics.Antioxidants (Basel, Switzerland) · 2026Review
- Selenoneine, a food chain component with potential neuroprotective effects against electrophilic mercury forms.Advances in neurotoxicology · 2026Article
- Protective effect of a novel hydrogel loaded with CM-UCMSCs on vitrified-thawed ovaries during in vitro culture.Frontiers in bioengineering and biotechnology · 2026Article
- Integrated Transcriptome-Metabolome Analysis Reveals the Flavonoids Metabolism Mechanism of Maize Radicle in Response to Low Temperature.Plants (Basel, Switzerland) · 2025Article
- Characterizing the Ultraviolet (UV) Screening Ability of L-5-Sulfanylhistidine Derivatives on Human Dermal Fibroblasts.Marine drugs · 2025Article
- Discovery of the selenium-containing antioxidant ovoselenol derived from convergent evolution.Nature chemistry · 2024Article
- Insights on the UV-Screening Potential of Marine-Inspired Thiol Compounds.Marine drugs · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ovothiol and ergothioneine are powerful antioxidants that readily react with oxidants by forming their respective disulfides. In fact, ovothiol is widely considered one of the most powerful natural antioxidants. However, for these antioxidants to be again involved in reacting with oxidants, they must be regenerated via the reduction of the disulfide bonds. In the present work, the regeneration of the antioxidants ovothiol and ergothioneine and their selenium analogues, by the closed-shell nucleophilic attack of glutathione, was investigated using density functional theory. From the calculated thermodynamic data, the attack of glutathione on OSSO and EYYE (where Y = S and/or Se) will readily occur in solution. Moreover, in comparison to the reference reaction GSH + GSSG → GSSG + GSH, all reactions are expected to be faster. Overall, the results presented herein show that the key antioxidant GSH should readily recycle ovothiol, ovoselenol, ergothioneine, and ergoseloneine from OYYO and EYYE (where Y = S and/or Se).
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.