Evidence map›Paper›PMID 36120034›Full record

ArticleACS omega2022

Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer's Disease.

Nan Wang, Wenjie Liu, Lijun Zhou, Wenwu Liu, Xu Liang, Xin Liu, Zihua Xu, Tianming Zhong, Qiong Wu, Xinming Jiao and 4 more

RetractedErratum issuedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 3 countries.

Nan WangDepartment of Pharmacy, General Hospital of Northern Theater Command, Shenyang110840, People's Republic of China.
Wenjie LiuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Lijun ZhouSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Wenwu LiuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Xu LiangSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Xin LiuSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Zihua XuDepartment of Pharmacy, General Hospital of Northern Theater Command, Shenyang110840, People's Republic of China.
Tianming ZhongDepartment of Pharmacy, General Hospital of Northern Theater Command, Shenyang110840, People's Republic of China.
Qiong WuDepartment of Pharmacy, General Hospital of Northern Theater Command, Shenyang110840, People's Republic of China.
Xinming JiaoSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Jiangxia ChenSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Xinyue NingSchool of Life Sciences and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Xiaowen JiangDepartment of Pharmacy, General Hospital of Northern Theater Command, Shenyang110840, People's Republic of China.
Qingchun ZhaoDepartment of Pharmacy, General Hospital of Northern Theater Command, Shenyang110840, People's Republic of China.ORCID https://orcid.org/0000-0001-9256-9971
Shenyang Pharmaceutical University · CNGeneral Hospital of Shenyang Military Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of Alzheimer's disease (AD) is very complex, and there are many hypotheses. Therefore, the development of a multi-target-directed-ligand may be an effective therapeutic strategy. Our previous study showed that notopterol (a natural product from

Identifiers

PMID36120034
PMCPMC9476211
OpenAlexW4293858388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.