ArticleNeuroscience and behavioral physiology2022
Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals.
Article in Neuroscience and behavioral physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anxiolytic-like effects of acute serotonin-releasing agents in zebrafish models of anxiety: experimental study and systematic review.Acta neuropsychiatrica · 2024Pooled it
- Closed-crown packaging system for stable, long-term neural recording in group-housed mice.Microsystems & nanoengineering · 2026Article
- Compartment-Specific Mitochondrial Proteomic Alterations in Rat Hippocampus Following Chronic Social Isolation Stress.International journal of molecular sciences · 2026Review
- Hippocampal Cdk5 is regulated by distinct stress paradigms in male and female mice.bioRxiv : the preprint server for biology · 2025Article
- Proteomic Signatures of Hippocampal Nonsynaptic and Synaptosome-Enriched Mitochondria in Rats Resilient to Chronic Social Isolation.Biomolecules · 2025Review
- Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats.Journal of neurochemistry · 2025Article
- Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber.Scientific reports · 2025Article
- Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice.EMBO reports · 2025Article
- Social isolation induces sexually aggressive behaviour in male Wistar rats.BMC neuroscience · 2025Article
- Social isolation: an integrated molecular web that disrupts cellular homeostasis.Frontiers in neuroscience · 2025Review
- Increased threat learning after social isolation in human adolescents.Royal Society open science · 2024Article
- Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction.Psychiatry research · 2024Article
- Brain-Bone Crosstalk in a Murine Polytrauma Model Promotes Bone Remodeling but Impairs Neuromotor Recovery and Anxiety-Related Behavior.Biomedicines · 2024Article
- Article
- Role ofVeterinary world · 2023Article
- The influence of long-term housing in enriched environment on behavior of normal rats and subjected to neonatal pro-inflammatory challenge.Brain, behavior, & immunity - health · 2023Article
- Nine-month-long Social Isolation Changes the Levels of Monoamines in the Brain Structures of Rats: A Comparative Study of Neurochemistry and Behavior.Neurochemical research · 2023Article
- Role of environmental enrichment on social interaction, anxiety, locomotion, and memory in Wistar rats under chronic methylphenidate intake.Frontiers in behavioral neuroscience · 2023Article
- Hepatic Inflammation and Apoptosis in Socially Isolated Rats: Effects of Vortioxetine Treatment.Iranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review describes the role of social isolation in the development of anxiety and depression-like behavior in rodents. The duration of social isolation, age from onset of social isolation, sex, species, and strain of animals, the nature of the model used, and other factors have been shown to have influences. The molecular-cellular mechanisms of development of anxiety and depression-like behavior under the influence of social isolation and the roles of the HHAS, oxidative and nitrosative stress, neuroinflammation, BDNF, neurogenesis, synaptic plasticity, as well as monoamines in these mechanisms are discussed. This review presents data on sex differences in the effects of social isolation, along with the effects of interactions with other types of stress, and the roles of an enriched environment and other factors in ameliorating the negative sequelae of social isolation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.