Evidence map›Paper›PMID 36119562›Full record

ArticleFrontiers in physics2022

Applications of Machine Learning to Improve the Clinical Viability of Compton Camera Based

Jerimy C Polf, Carlos A Barajas, Stephen W Peterson, Dennis S Mackin, Sam Beddar, Lei Ren, Matthias K Gobbert

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 25 citations in OpenAlex.

  1. Emerging technologies for cancer therapy using accelerated particles.Progress in particle and nuclear physics · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. 3DPhysics in medicine and biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jerimy C PolfDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, United States.
Carlos A BarajasDepartment of Mathematics and Statistics, University of Maryland Baltimore County, Baltimore, MD, United States.
Stephen W PetersonDepartment of Physics, University of Cape Town, Rondebosch, South Africa.
Dennis S MackinDepartment of Medical Physics, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Sam BeddarDepartment of Medical Physics, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States.
Lei RenDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, United States.
Matthias K GobbertDepartment of Mathematics and Statistics, University of Maryland Baltimore County, Baltimore, MD, United States.
The University of Texas MD Anderson Cancer Center · USUniversity of Maryland, Baltimore · USUniversity of Maryland, Baltimore County · USUniversity of Cape Town · ZA

Funding

Prompt Gamma Imaging for the in-vivo range verification during proton radiotherapyR01CA187416 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BEDDAR, SAM, KAYE, WILLIAM ROBERT · 2015 to 2019
$2.7M
NCI NIH HHS R01 CA187416
6 · The paper itself

Abstract

We studied the application of a deep, fully connected Neural Network (NN) to process prompt gamma (PG) data measured by a Compton camera (CC) during the delivery of clinical proton radiotherapy beams. The network identifies 1) recorded "bad" PG events arising from background noise during the measurement, and 2) the correct ordering of PG interactions in the CC to help improve the fidelity of "good" data used for image reconstruction. PG emission from a tissue-equivalent target during irradiation with a 150 MeV proton beam delivered at clinical dose rates was measured with a prototype CC. Images were reconstructed from both the raw measured data and the measured data that was further processed with a neural network (NN) trained to identify "good" and "bad" PG events and predict the ordering of individual interactions within the good PG events. We determine if NN processing of the CC data could improve the reconstructed PG images to a level in which they could provide clinically useful information about the

Indexed as

compton camerain vivo imagingprompt gammaproton pencil beamproton radiotherapyrange verification

Identifiers

PMID36119562
PMCPMC9481064
OpenAlexW4223454689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.