ArticleEClinicalMedicine2022
Association of longitudinal repeated measurements of frailty index with mortality: Cohort study among community-dwelling older adults.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of frailty and mortality risk in community-dwelling older adults: a systematic review and meta-analysis of 59 international prospective cohort studies.BMC public health · 2026Pooled it
- Correlation of frailty assessment metrics in one-year follow-up of aged care residents: a sub-study of a randomised controlled trial.Aging clinical and experimental research · 2023Trial
- The application value of frailty assessment tools in the perioperative period: A narrative review.Journal of anesthesia and translational medicine · 2026Review
- Social and clinical frailty indices in aging mice: a comparative analysis of longitudinal and cross-sectional designs.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Article
- Metabolic syndrome severity and all-cause mortality in the CLHLS biomarker subsample of older Chinese adults.Frontiers in public health · 2026Article
- Association between frailty and breast cancer incidence and construction of a breast cancer prediction model based on machine learning.Frontiers in public health · 2026Article
- A survey on the trajectory of frailty in the middle-aged and elderly population in the Chengdu community: a retrospective observational study.BMC public health · 2025Observational
- Association between the healthy eating index and sarcopenia in Chinese elderly: a cross-sectional study.BMC geriatrics · 2025Article
- Frailty transition and burden on mortality risk in middle-aged and older population: a prospective cohort study.Scientific reports · 2024Article
- Investigating Frailty, Polypharmacy, Malnutrition, Chronic Conditions, and Quality of Life in Older Adults: Large Population-Based Study.JMIR public health and surveillance · 2024Article
- Association of frailty with mortality in cancer survivors: results from NHANES 1999-2018.Scientific reports · 2024Article
- Frailty predicts all-cause and cause-specific mortality among older adults in Austria: 8-year mortality follow-up of the Austrian Health Interview Survey (ATHIS 2014).BMC geriatrics · 2024Article
- Poor Nutritional Status Is Associated with Death in a Population of Dialyzed Older Persons.The Journal of frailty & aging · 2024Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty indices (FIs), defined by accumulation of health deficits, have been shown to be strongly related to mortality in older adults. However, previous studies mostly relied on FI measurement at a single point of time. We aimed to investigate the association of frailty with mortality according to longitudinal repeated measurements of FI in a large population-based cohort study in Germany. Methods: Among 9912 men and women aged 50-75 years living in Saarland, Germany and recruited in the ESTHER study in 2000-2002, a FI based on 30 deficits was determined at baseline, 2-, 5-, 8-, and 11-year follow-up. Hazard ratios (HRs) were calculated to assess the associations of FI with all-cause mortality and cause-specific mortality during 14 years of follow-up using Cox proportional hazards models that included FI as a time-varying covariate. Findings: During the 14-year follow-up, a total of 2483 deaths were observed, of which 859 and 863 were due to cancer and cardiovascular diseases (CVD), respectively. The time-varying FI showed consistently strong associations with mortality throughout 14 years of follow-up, with HRs (95% confidence intervals) for frail (FI≥ 0·35) versus non-frail (FI≤ 0·11) participants of 4·72 (4.05-5.51), 2·55 (1·95-3·34) and 7·52 (5·69-9·94) for all-cause, cancer, and CVD mortality, respectively. Gradually decreasing associations with increasing length of follow-up would have been obtained by using baseline FI only. Interpretation: Longitudinal repeated measures of FI show strong, consistent associations with mortality, especially CVD mortality, throughout extended periods of follow-up among community-dwelling older adults. Funding: The ESTHER study was funded by grants from the Baden-Württemberg state Ministry of Science, Research and Arts (Stuttgart, Germany), the Federal Ministry of Education and Research (Berlin, Germany), the Federal Ministry of Family Affairs, Senior Citizens, Women and Youth (Berlin, Germany), and the Saarland State Ministry of Health, Social Affairs, Women and the Family (Saarbrücken, Germany).
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