Evidence map›Paper›PMID 36119395›Full record

ReviewCritical care explorations2022

A Systematic Review and Meta-Analysis Evaluating Geographical Variation in Outcomes of Cancer Patients Treated in ICUs.

Lama H Nazer, Maria A Lopez-Olivo, Anne Rain Brown, John A Cuenca, Michael Sirimaturos, Khader Habash, Nada AlQadheeb, Heather May, Victoria Milano, Amy Taylor and 1 more

Abstract readReview
In one paragraph

Review in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Understanding Outcomes in Onco-critical Care: The Role of Frailty and Organ Failure.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lama H NazerDepartment of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
Maria A Lopez-OlivoDepartment of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Anne Rain BrownDepartment of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX.
John A CuencaDepartment of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
Michael SirimaturosDepartment of Pharmacy, Houston Methodist Hospital, Houston, TX.
Khader HabashDepartment of Pharmacy, King Hussein Cancer Center, Amman, Jordan.
Nada AlQadheebDepartment of Pharmacy, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Heather MayDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Victoria MilanoDepartment of Pharmacy, University of New Mexico Hospitals, Albuquerque, NM.
Amy TaylorMedical Library, Houston Methodist Hospital, Houston, TX.
Joseph L NatesDepartment of Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Improving decision-making in patients with resectable melanoma and pre-existing autoimmune disease considering immune checkpoint inhibitionK08CA237619 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOPEZ-OLIVO, MARIA DE LOS ANGELES · 2020 to 2024
$938k
NCI NIH HHS K08 CA237619NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

The reported mortality rates of cancer patients admitted to ICUs vary widely. In addition, there are no studies that examined the outcomes of critically ill cancer patients based on the geographical regions. Therefore, we aimed to evaluate the mortality rates among critically ill cancer patients and provide a comparison based on geography. DATA SOURCES: PubMed, EMBASE, and Web of Science. STUDY SELECTION: We included observational studies evaluating adult patients with cancer treated in ICUs. We excluded non-English studies, those with greater than 30% hematopoietic stem cell transplant or postsurgical patients, and those that evaluated a specific type of critical illness, stage of malignancy, or age group. DATA EXTRACTION: Two reviewers independently applied eligibility criteria, assessed quality, and extracted data. Studies were classified based on the continent in which they were conducted. Primary outcomes were ICU and hospital mortality. We pooled effect sizes by geographical region. DATA SYNTHESIS: Forty-six studies were included (

conclusionsMore than half of cancer patients admitted to ICUs survived hospitalization. However, there was wide variability in the mortality rates, as well as the number of available studies among geographical regions. This variability suggests an opportunity to improve outcomes worldwide, through optimizing practice and research.

Indexed as

cancercritical illnessmeta-analysismortalityoutcomes

Identifiers

PMID36119395
PMCPMC9473777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.