Evidence map›Paper›PMID 36119152›Full record

ArticleComputational statistics & data analysis2022

sJIVE: Supervised Joint and Individual Variation Explained.

Elise F Palzer, Christine H Wendt, Russell P Bowler, Craig P Hersh, Sandra E Safo, Eric F Lock

Open access · greenAbstract read
In one paragraph

Article in Computational statistics & data analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  4. Integrative Analysis of Multimodal Omics Data.Annual review of statistics and its application · 2026
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  12. mvlearnR and Shiny App for multiview learning.Bioinformatics advances · 2024
    Article
  13. Joint and Individual Component Regression.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024
    Article
  14. Bayesian predictive modeling of multi-source multi-way data.Computational statistics & data analysis · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Elise F PalzerDivision of Biostatistics, University of Minnesota, Minneapolis, 55455, USA.
Christine H WendtDivision of Pulmonary, Allergy and Critical Care, University of Minnesota, Minneapolis, 55455, USA.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA.
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sandra E SafoDivision of Biostatistics, University of Minnesota, Minneapolis, 55455, USA.
Eric F LockDivision of Biostatistics, University of Minnesota, Minneapolis, 55455, USA.
University of Minnesota · USBrigham and Women's Hospital · USNational Jewish Health · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Multi-omic networks associated with COPD progression in TOPMed CohortsR01HL152735 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BANAEI-KASHANI, FARNOUSH, BOWLER, RUSSELL PAUL · 2020 to 2023
$3.1M
Statistical and Machine Learning Methods to Address Biomedical Challenges for Integrating Multi-view Data (Supplement)R35GM142695 · NIGMS · UNIVERSITY OF MINNESOTA · PI Sandra E Safo · 2021 to 2026
$3.0M
Identifying Biomarkers from Multi-source, Multi-way DataR01GM130622 · NIGMS · UNIVERSITY OF MINNESOTA · PI LOCK, ERIC F · 2019 to 2023
$1.5M
NHLBI NIH HHS R01 HL152735NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIGMS NIH HHS R01 GM130622NIGMS NIH HHS R35 GM142695
6 · The paper itself

Abstract

Analyzing multi-source data, which are multiple views of data on the same subjects, has become increasingly common in molecular biomedical research. Recent methods have sought to uncover underlying structure and relationships within and/or between the data sources, and other methods have sought to build a predictive model for an outcome using all sources. However, existing methods that do both are presently limited because they either (1) only consider data structure shared by all datasets while ignoring structures unique to each source, or (2) they extract underlying structures first without consideration to the outcome. The proposed method, supervised joint and individual variation explained (sJIVE), can simultaneously (1) identify shared (joint) and source-specific (individual) underlying structure and (2) build a linear prediction model for an outcome using these structures. These two components are weighted to compromise between explaining variation in the multi-source data and in the outcome. Simulations show sJIVE to outperform existing methods when large amounts of noise are present in the multi-source data. An application to data from the COPDGene study explores gene expression and proteomic patterns associated with lung function.

Indexed as

Data integrationDimension reductionGenomic dataHigh-dimensional predictionMulti-source dataMulti-view learning

Identifiers

PMID36119152
PMCPMC9481062
OpenAlexW3134872775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.