Evidence map›Paper›PMID 36119058›Full record

ArticleFrontiers in immunology2022

Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine.

Jake S O'Donnell, Ariel Isaacs, Virginie Jakob, Celia Lebas, James B Barnes, Patrick C Reading, Paul R Young, Daniel Watterson, Patrice M Dubois, Nicolas Collin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

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  11. Development of semisynthetic saponin immunostimulants.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jake S O'DonnellThe Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Ariel IsaacsThe Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Virginie JakobVaccine Formulation Institute, Geneva, Switzerland.
Celia LebasVaccine Formulation Institute, Geneva, Switzerland.
James B BarnesThe WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Patrick C ReadingThe WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Paul R YoungThe Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Daniel WattersonThe Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
Patrice M DuboisVaccine Formulation Institute, Geneva, Switzerland.
Nicolas CollinVaccine Formulation Institute, Geneva, Switzerland.
Keith J ChappellThe Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AUSwiss Vaccine Research Institute · CHPeter Doherty Institute · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various chemical adjuvants are available to augment immune responses to non-replicative, subunit vaccines. Optimized adjuvant selection can ensure that vaccine-induced immune responses protect against the diversity of pathogen-associated infection routes, mechanisms of infectious spread, and pathways of immune evasion. In this study, we compare the immune response of mice to a subunit vaccine of Middle Eastern respiratory syndrome coronavirus (MERS-CoV) spike protein, stabilized in its prefusion conformation by a proprietary molecular clamp (MERS SClamp) alone or formulated with one of six adjuvants: either (

Indexed as

SaponinsToll-Like Receptor 4Adjuvants, ImmunologicAdjuvants, PharmaceuticAluminum HydroxideAnimalsCD8-Positive T-LymphocytesDisaccharidesEmulsionsImmunoglobulin GInterleukin-2LiposomesMicePhosphorylcholineSpike Glycoprotein, CoronavirusSqualeneAdjuvants, ImmunologicAdjuvants, PharmaceuticAluminum HydroxideDisaccharidesEmulsionsImmunoglobulin GInterleukin-2LiposomesPhosphorylcholineSaponinsSpike Glycoprotein, CoronavirusSqualeneToll-Like Receptor 4Vaccines, SubunitWateradjuvantantibodyMERST cellvaccine

Identifiers

PMID36119058
PMCPMC9478912
OpenAlexW4294218773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.