Evidence map›Paper›PMID 36119034›Full record

ArticleFrontiers in immunology2022

The role of the different CD3γ domains in TCR expression and signaling.

Beatriz Garcillán, Rebeca F Megino, Marta Herrero-Alonso, Alberto C Guardo, Veronica Perez-Flores, Claudia Juraske, Vincent Idstein, Jose M Martin-Fernandez, Carsten Geisler, Wolfgang W A Schamel and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Beatriz GarcillánDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Rebeca F MeginoDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Marta Herrero-AlonsoDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Alberto C GuardoDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Veronica Perez-FloresDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Claudia JuraskeSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Vincent IdsteinSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Jose M Martin-FernandezDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Carsten GeislerThe LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Wolfgang W A SchamelSignaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
Ana V MarinDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Jose R RegueiroDepartment of Immunology, Ophthalmology and Ear, Nose and Throat (ENT), Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
Research Institute Hospital 12 de Octubre · ESUniversity Medical Center Freiburg · DEUniversity of Copenhagen · DKUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CD3 subunits of the T-cell antigen receptor (TCR) play a central role in regulation of surface TCR expression levels. Humans who lack CD3γ (γ

Indexed as

Interleukin-2Tumor Necrosis Factor-alphaCD3 ComplexHumansLeucinePhorbol EstersReceptors, Antigen, T-CellCD3 antigen, gamma chainCD3 ComplexInterleukin-2LeucinePhorbol EstersReceptors, Antigen, T-CellTumor Necrosis Factor-alphaCD3 chimerasCD3γCD3δdomainsT cell receptor

Identifiers

PMID36119034
PMCPMC9478619
OpenAlexW4294193037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.