Evidence map›Paper›PMID 36118914›Full record

ArticleEvolution, medicine, and public health2022

An orally administered drug prevents selection for antibiotic-resistant bacteria in the gut during daptomycin therapy.

Valerie J Morley, Derek G Sim, Aline Penkevich, Robert J Woods, Andrew F Read

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evolution, medicine, and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Valerie J MorleyDepartment of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, USA.ORCID https://orcid.org/0000-0001-6805-7562
Derek G SimDepartment of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, USA.
Aline PenkevichDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Robert J WoodsDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-0679-9998
Andrew F ReadDepartment of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, PA, USA.ORCID https://orcid.org/0000-0001-7604-7903
Pennsylvania State University · USUniversity of Michigan · US

Funding

Dynamical modeling of hospital transmission and antibiotic resistance evolution in a multidrug resistant nosocomial pathogenR01AI143852 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOODS, ROBERT J · 2019 to 2023
$2.9M
Population Dynamics of Rotavirus: A Combined Theoretical, Bioinformatic and Laboratory Based ApproachK08AI119182 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOODS, ROBERT J · 2016 to 2020
$960k
NIAID NIH HHS K08 AI119182NIAID NIH HHS R01 AI143852
6 · The paper itself

Abstract

Background and objectives: Previously, we showed proof-of-concept in a mouse model that oral administration of cholestyramine prevented enrichment of daptomycin-resistant Methodology: Mice with GI Results: Cholestyramine prevented the enrichment of diverse resistance mutations that emerged Conclusions and implications: Cholestyramine prevented the enrichment of diverse daptomycin-resistance mutations in intestinal

Indexed as

antimicrobial resistanceantimicrobial stewardshipdaptomycinEnterococcus faecium

Identifiers

PMID36118914
PMCPMC9472784
OpenAlexW4293051893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.