Evidence map›Paper›PMID 36118825›Full record

ArticleComputational and mathematical methods in medicine2022

The Effect of PD-1 Inhibitor Combined with Chemotherapy on the Level of Peripheral Blood T Lymphocytes among Patients with Non-Small-Cell Lung Cancer and Its Relationship with Prognosis.

Yun Zhao, Jianbo He, Shaozhang Zhou, Ruiling Ning, Wenhua Zhao, Huilin Wang, Cuiyun Su, Wei Jiang, Xiaoning Zhong, Qitao Yu

Abstract read
In one paragraph

Article in Computational and mathematical methods in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun ZhaoDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Jianbo HeDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Shaozhang ZhouDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Ruiling NingDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Wenhua ZhaoDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Huilin WangDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Cuiyun SuDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Wei JiangDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.
Xiaoning ZhongPulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021 Guangxi, China.ORCID https://orcid.org/0000-0001-7426-2183
Qitao YuDepartment of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China.ORCID https://orcid.org/0000-0003-1376-6649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the effect of combined treatment of PD-1 inhibitor and chemotherapy on the level of peripheral blood T lymphocytes in non-small-cell lung cancer (NSCLC) patients and its relationship with prognosis. Methods: Retrospective analysis was conducted on 150 NSCLC patients treated in Guangxi Medical University Affiliated Tumor Hospital from June 2018 to September 2020, including 77 patients treated with PD-1 inhibitor combined with chemotherapy as the observation group (OG) and 73 patients with chemotherapy alone as the control group (CG). Therapeutic efficacy, immune function indexes, serum tumor markers, incidence of adverse reactions during hospitalization, 1-year survival rate, and life quality after 6 months of treatment were observed and compared between two groups. Results: Compared to the CG, the therapeutic effect of OG was evidently better. Six months after treatment, levels of CD4 Conclusion: For NSCLC patients, the PD-1 inhibitor given on the basis of chemotherapy can further improve the clinical efficacy and improve immune function and long-term survival rate of patients on the premise of ensuring the safety of treatment, which is worth promoting in clinical practice.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAntigens, NeoplasmBiomarkers, TumorCarcinoembryonic AntigenChinaHumansImmune Checkpoint InhibitorsKeratin-19PrognosisRetrospective StudiesT-Lymphocytesantigen CYFRA21.1Antigens, NeoplasmBiomarkers, TumorCarcinoembryonic AntigenImmune Checkpoint InhibitorsKeratin-19

Identifiers

PMID36118825
PMCPMC9473904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.