Evidence map›Paper›PMID 36118754›Full record

ArticleFrontiers in nutrition2022

Fish oil supplementation of rats fed a high fat diet during pregnancy improves offspring insulin sensitivity.

Vidit V Satokar, Mark H Vickers, Clare M Reynolds, Anna P Ponnampalam, Elwyn C Firth, Manohar L Garg, Carolyn J Barrett, Wayne S Cutfield, Benjamin B Albert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Vidit V SatokarLiggins Institute, University of Auckland, Auckland, New Zealand.
Mark H VickersLiggins Institute, University of Auckland, Auckland, New Zealand.
Clare M ReynoldsLiggins Institute, University of Auckland, Auckland, New Zealand.
Anna P PonnampalamManaaki Mānawa - The Centre for Heart Research, Department of Physiology, University of Auckland, Auckland, New Zealand.
Elwyn C FirthLiggins Institute, University of Auckland, Auckland, New Zealand.
Manohar L GargNutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
Carolyn J BarrettManaaki Mānawa - The Centre for Heart Research, Department of Physiology, University of Auckland, Auckland, New Zealand.
Wayne S CutfieldLiggins Institute, University of Auckland, Auckland, New Zealand.
Benjamin B AlbertLiggins Institute, University of Auckland, Auckland, New Zealand.
University of Auckland · NZUniversity College Dublin · IEUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In rats, a maternal high-fat diet (HFD) leads to adverse metabolic changes in the adult offspring, similar to the children of mothers with obesity during pregnancy. Supplementation with a high dose of fish oil (FO) to pregnant rats fed a HFD has been shown to prevent the development of insulin resistance in adult offspring. However, the effects of supplementation at a translationally relevant dose remain unknown. Aim: To determine whether supplementation with a human-relevant dose of FO to pregnant rats can prevent the long-term adverse metabolic and cardiovascular effects of a maternal HFD on adult offspring. Methods: Female rats ( Results: There was an interaction between maternal diet and FO supplementation on insulin sensitivity ( Conclusion: The effects of a human-relevant dose of maternal FO on offspring outcomes were dependent on the maternal diet, so that FO was beneficial to the offspring if the mother consumed a HFD, but deleterious if the mother consumed a control diet. This study suggests that supplementation with FO should be targeted to women expected to have abnormalities of metabolism such as those with overweight and obesity.

Indexed as

developmental programmingDOHaDfish oilinsulin sensitivitymetabolismomega-3pregnancyrat

Identifiers

PMID36118754
PMCPMC9481032
OpenAlexW4294168344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.