Evidence map›Paper›PMID 36118743›Full record

ArticleFrontiers in nutrition2022

Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study.

Fjorida Llaha, Valerie Cayssials, Marta Farràs, Antonio Agudo, Maria Sandström, Anne Kirstine Eriksen, Anne Tjønneland, Marie-Christine Boutron-Ruault, Nasser Laouali, Thérèse Truong and 24 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Dietary Pattern and Risk of Thyroid Cancer: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
  2. The Effect of Mediterranean Diet on Thyroid Gland Activity.International journal of molecular sciences · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 9 countries.

Fjorida LlahaUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Valerie CayssialsUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Marta FarràsUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Antonio AgudoUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Maria SandströmDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Anne Kirstine EriksenUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
Anne TjønnelandUnit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
Marie-Christine Boutron-RuaultUniversity Paris-Saclay, University of Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Team "Exposome and Heredity", Villejuif, France.
Nasser LaoualiUniversity Paris-Saclay, University of Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Team "Exposome and Heredity", Villejuif, France.
Thérèse TruongUniversity Paris-Saclay, University of Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut National de la Santé et de la Recherche Médicale (INSERM), Gustave Roussy, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Team "Exposome and Heredity", Villejuif, France.
Charlotte Le CornetDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Matthias SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - Institute for the Study and Prevention of Cancer, Florence, Italy.
Vittorio KroghEpidemiology and Prevention Unit, Fondazione Istituto Nazionale dei Tumori (IRCCS), Milan, Italy.
Simona SignorielloDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Vanvitelli University, Naples, Italy.
Rosario TuminoHyblean Association for Epidemiological Research (AIRE -ONLUS), Ragusa, Italy.
Fulvio RicceriDepartment of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Guri SkeieDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT) - The Arctic University of Norway, Tromsø, Norway.
Torill Miriam Enget JensenDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT) - The Arctic University of Norway, Tromsø, Norway.
Sairah Lai Fa ChenDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø (UiT) - The Arctic University of Norway, Tromsø, Norway.
Cristina LasherasDepartment of Functional Biology. Medical School. University of Oviedo, Oviedo, Spain.
Miguel Rodriguez-BarrancoEscuela Andaluza de Salud Pública, Granada, Spain.
Pilar AmianoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
José María HuertaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Marcela GuevaraCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Martin AlmquistDepartment of Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
Lena Maria NilsonDepartment of Epidemiology and Global Health, Umeå University, Umeå, Sweden.
Joakim HenningsDepartment of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden.
Keren PapierCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Alicia HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Elisabete WeiderpassInternational Agency for Research on Cancer - World Health Organization (IARC-WHO), Lyon, France.
Sabina RinaldiInternational Agency for Research on Cancer - World Health Organization (IARC-WHO), Lyon, France.
Raul Zamora-RosUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Institut Català d'Oncologia · ESUiT The Arctic University of Norway · NOUmeå University · SECentre International de Recherche sur le Cancer · FRDanish Cancer Society · DKBiogipuzkoa Health Research Institute · ESCentre de recherche en Epidémiologie et Santé des Populations · FRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Cancer Research Center · DEGerman Institute of Human Nutrition · DEHeidelberg University · DEImperial College London · GBInserm · FRInstitut d'Investigació Biomédica de Bellvitge · ESInstituto de Salud Pública de Navarra · ESInstituto Murciano de Investigación Biosanitaria · ESInternational Flame Research Foundation · ITLund University · SEPiedmont Reference Center for Epidemiology and Cancer Prevention · IT

Funding

Cancer Research UK 29017World Health Organization 001
6 · The paper itself

Abstract

Background: The Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Over 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Results: Adherence to the arMED score was not associated with the risk of differentiated TC (HR Conclusions: Our study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.

Indexed as

cohortEPIC studyintakemeatMediterranean diet (MD)thyroid cancer (TC)

Identifiers

PMID36118743
PMCPMC9481277
OpenAlexW4294219349

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.