Evidence map›Paper›PMID 36118721›Full record

ArticleOpen veterinary journal

Secretory carcinoma of the canine mammary gland with nodal and bone metastases: Case report.

Halana do Carmo Silva, Marina Possa Dos Reys, Geovanni Dantas Cassali, Fernanda Rezende Souza, Rodrigo Dos Santos Horta, Bruna Voltolin de Sena, Adriano Lima Stelzer Bindaco, Ana Carolina Jesus de Pinto, Tayse Domingues de Souza, Mayra Cunha Flecher

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PubMed Full text at PMC Publisher
In one paragraph

Article in Open veterinary journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Halana do Carmo SilvaDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Marina Possa Dos ReysDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Geovanni Dantas CassaliDepartment of General Pathology, Laboratory of Comparative Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Fernanda Rezende SouzaDepartment of General Pathology, Laboratory of Comparative Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Rodrigo Dos Santos HortaDepartment of Veterinary Medicine and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Bruna Voltolin de SenaDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Adriano Lima Stelzer BindacoDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Ana Carolina Jesus de PintoDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Tayse Domingues de SouzaDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Mayra Cunha FlecherDepartment of Veterinary Medicine, Universidade Vila Velha, Vila Velha, Brazil.
Universidade Vila Velha · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Secretory carcinoma is a rare histological type of breast neoplasm in humans and dogs that is characterized by the presence of intracellular and extracellular eosinophilic secretions. Case Description: In this case report, we describe the cytological, histological, and immunohistochemical characteristics of secretory mammary carcinoma in a 10-year-old mixed-breed female dog with nodal and bone metastases. The bitch had a history of claudication and a mass in the left humeral scapular region, which revealed osteolysis of the proximal humerus on radiography. Fine-needle aspiration cytology revealed numerous neoplastic cells arranged mostly in cohesive groups but sometimes isolated, that contained cytoplasmic vacuoles and had a moderate-to-high nucleus: cytoplasm ratio with frequent karyomegaly and evident nucleoli. Histologically, the neoplasm was organized in solid, tubular structures with luminal spaces filled with eosinophilic secretions and was composed of cells with clear cytoplasm and prominent vacuoles that pushed the nuclei to the periphery, resembling signet ring cells. The extracellular and intracytoplasmic material of the epithelial cells was positive for periodic acid-Schiff staining and immunoreactive for alpha-lactalbumin. Two chemotherapy sessions were performed, but 1 month after surgery, the clinical condition worsened, and euthanasia was elected, accounting for 133 days of survival after surgical removal of the tumor. Conclusion: The bitch presented with secretory mammary carcinoma with nodal and bone metastases, and histological and immunohistochemical characteristics were important for diagnosis. The morphological and immunohistochemical characteristics of this carcinoma were similar to those observed in humans. Mammary gland secretory carcinoma with bone metastasis must be included as a differential diagnosis among canine mammary gland carcinomas showing cellular morphological characteristics of intracytoplasmic vacuolization and eosinophilic secretion.

Indexed as

Bone NeoplasmsBreast NeoplasmsCarcinomaDog DiseasesAnimalsDogsFemaleHumansLactalbuminPeriodic AcidLactalbuminPeriodic AcidAlpha-lactalbuminDogMammary gland carcinoma

Identifiers

PMID36118721
PMCPMC9473362
OpenAlexW4293424050

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.