ArticleFrontiers in aging neuroscience2022
Dynamic functional connections in leukoaraiosis patients without cognitive impairment: A pilot study.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Abnormal dynamic functional connectivity in young nondisabling intracerebral hemorrhage patients.Annals of clinical and translational neurology · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Leukoaraiosis (LA) is a major public issue that affects elderly adults. However, the underlying neuropathological mechanism of LA without cognitive impairment requires examination. The present study aimed to explore the dynamic functional network connectivity (dFNC) in LA patients without cognitive impairment. Methods: Twenty-three patients with LA and 20 well-matched healthy controls were recruited for the present study. Each subject underwent magnetic resonance imaging (MRI) scanning and cognition evaluations. Spatial independent component analysis was conducted to evaluate dynamic functional connectivity. The differences in dFNC were determined and correlated with cognitive performance. Results: Compared with controls, LA without cognitive impairment showed aberrant dFNC in State 1, involving increased connectivity in the default mode network (DMN) with the executive control network (ECN). In addition, decreased connectivity in the DMN with the salience network (SN) was found in State 3. Furthermore, the decreased number of transitions between states was positively associated with the visuospatial/executive score (Spearman's rho = 0.452, Conclusion: These findings enrich our understanding of the neural mechanisms underlying LA and may serve as a potential imaging biomarker for investigating and recognizing the LA at an early stage.
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