ArticleGeneral psychiatry2022
A cohort study of adolescents with depression in China: tracking multidimensional outcomes and early biomarkers for intervention.
Article in General psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Emotion regulation difficulties and experiential avoidance in adolescents with non-suicidal self-injury: a latent profile and moderation analysis.Frontiers in psychiatry · 2026Article
- Article
- Prophylactic effect of omega-3 polyunsaturated fatty acids monotherapy in preventing recurrent major depressive disorder: A randomized controlled trial.BioMedicine · 2025Article
- Remission trajectories and cognitive function in hospitalized youth with depressive episodes.Frontiers in psychiatry · 2025Article
- Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood.Molecular psychiatry · 2024Article
- Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts.European child & adolescent psychiatry · 2024Article
- Ferroptosis: a new antidepressant pharmacological mechanism.Frontiers in pharmacology · 2023Review
- High frequency strong current tACS：a new dawn of non-drug therapy for patients with major depressive disorder.General psychiatry · 2023Article
- Development of the Life Gatekeeper suicide prevention training programme in China: a Delphi study.General psychiatry · 2023Article
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11 authors.
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Abstract
Background: Depression in adolescents is recognised as a global public health concern, but little is known about the trajectory of its clinical symptoms and pathogenesis. Understanding the nature of adolescents with depression and identifying early biomarkers can facilitate personalised intervention and reduce disease burden. Aims: To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis, as well as response to treatment, prognosis and guidance for early identification and intervention. Methods: This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression (sBEAD). We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years. Multidimensional clinical presentations and objective indicators are collected at baseline, weeks 4, 8, 12 and 24, and years 1, 2, 3, 4 and 5. Conclusions: To the best of our knowledge, this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression. This study aims at providing early individualised interventions for young, depressed patients to reduce the burden of disease. Trial registration number: Chinese Clinical Trial Registry ID ChiCTR2100049066.
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