ArticleFrontiers in veterinary science2022
Overexpression of GPR41 attenuated glucose production in propionate-induced bovine hepatocytes.
Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Effects of Bioactive Microalgal Pigment Intake on Metabolic Parameters, Cecal Distribution and Short-Chain Fatty Acids in a Diabetic Rat Model.Life (Basel, Switzerland) · 2026Article
- Differential Regulation of Ruminal Microbial Community Structure and Functional Pathways in Sheep Supplemented with Linseed Oil or Sunflower Oil.Animals : an open access journal from MDPI · 2026Article
- The Effects of Indigo Waste Silage Prepared with Additives on Feed Availability, Rumen Fermentation Patterns, Blood Metabolites, and Hematological Indices in Beef Cattle.Veterinary sciences · 2024Article
- Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes.Animal bioscience · 2023Article
- A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes.International journal of molecular sciences · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Bovine liver mainly utilizes the propionate as a gluconeogenic substrate to synthesize the glucose. However, the mechanism underlying the regulatory effects of propionate on the glucose production in bovine hepatocytes remains less known. Previous studies have demonstrated G protein-coupled receptor 41 (GPR41) as receptors for propionate. We hypothesized that propionate may regulate the glucose production by GPR41 in bovine hepatocytes. Therefore, the aim of the study was to investigate the regulatory effects of propionate and GPR41 on glucose production in bovine hepatocytes. Hepatocytes with GPR41 overexpression were incubated in the presence of either 0 or 3 mM propionate for 24 h. These results showed that the expression of phosphoenolpyruvate carboxykinase 2 (PCK2) and pyruvate carboxylase (PC) genes involved in gluconeogenesis was enhanced (
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