Evidence map›Paper›PMID 36118156›Full record

ArticleInternational journal of cardiology. Heart & vasculature2022

Lipoprotein (a) levels and vulnerable characteristics in nonculprit plaque in patients with acute coronary syndrome.

Ayami Kato, Daisuke Kinoshita, Takako Nagata, Kiyoshi Asakura, Masahiro Katamine, Aritomo Katsura, Takuya Hashimoto, Yoshiyasu Minami, Junya Ako

Abstract read
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ayami KatoDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Daisuke KinoshitaDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Takako NagataDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Kiyoshi AsakuraDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Masahiro KatamineDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Aritomo KatsuraDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Takuya HashimotoDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Yoshiyasu MinamiDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Junya AkoDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: High plasma levels of Lp(a) are associated with a worse prognosis in patients with coronary artery disease. The aim of the present study is to clarify the association between high lipoprotein a [Lp(a)] levels and vulnerable characteristics of nonculprit plaques in patients with acute coronary syndrome (ACS). Methods: A total of 185 consecutive patients with ACS who underwent optical coherence tomography imaging of nonculprit plaques in the culprit vessels were enrolled. Patients were divided into the high Lp(a) group (≥30 mg/dL; 50 nonculprit plaques in 49 patients) or the low Lp(a) group (<30 mg/dL; 139 nonculprit plaques in 136 patients). Results: The prevalence of thin-cap fibroatheroma (TCFA) was significantly higher in the high Lp(a) group than in the low Lp(a) group (38.0 vs. 21.6%, Conclusions: High Lp(a) levels were associated with a high prevalence of TCFA in nonculprit plaques among patients with ACS, particularly in patients with plaque erosion. The present results may partly explain the pathogenesis of worse clinical outcomes in patients with ACS and a high Lp(a) level as shown in clinical studies.

Indexed as

Optical coherence tomographyPlaque ruptureThin-cap fibroatheroma

Identifiers

PMID36118156
PMCPMC9474856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.