ArticleFrontiers in cellular and infection microbiology2022
Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference.
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Gut microbial community structure, metabolic signature, and resistome in dyslipidemia: implications for cardiovascular disease management.Microbiology spectrum · 2026Article
- Improving DirectLiNGAM for high-dimensional microbiome data: roots screening and eBIC based model selection.Frontiers in systems biology · 2026Article
- Gut Microbiota Associated With Hyperlipidemia: A Systematic Review and Meta-Analysis.Gastro hep advances · 2026Review
- Diet and the gut microbiota profiles in individuals at risk of chronic heart failure - A review on the Asian population.Asia Pacific journal of clinical nutrition · 2025Review
- Clade-specific extracellular vesicles from Akkermansia muciniphila mediate competitive colonization via direct inhibition and immune stimulation.Nature communications · 2025Article
- Characterization of the gut microbiota in polycystic ovary syndrome with dyslipidemia.BMC microbiology · 2024Article
- Genetically predicted gut microbiota mediate the association between plasma lipidomics and primary sclerosing cholangitis.BMC gastroenterology · 2024Article
- Prediction and causal inference of hyperuricemia using gut microbiota.Scientific reports · 2024Article
- Causality of the gut microbiome and atherosclerosis-related lipids: a bidirectional Mendelian Randomization study.BMC cardiovascular disorders · 2024Article
- Variations in the Relative Abundance of Gut Bacteria Correlate with Lipid Profiles in Healthy Adults.Microorganisms · 2023Article
- Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease.Circulation research · 2023Review
- Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results.Frontiers in cellular and infection microbiology · 2023Article
- Exploring the causal effects of the gut microbiome on serum lipid levels: A two-sample Mendelian randomization analysis.Frontiers in microbiology · 2023Article
- Characteristic alterations of gut microbiota in uncontrolled gout.Journal of microbiology (Seoul, Korea) · 2022Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate the causal relationship between GM and DL. A total of 79 men and 82 women aged 40 years or older living in Shika-machi, Ishikawa Prefecture, Japan were included in the analysis, and their clinical information was investigated. DNA extracted from the GM was processed to sequence the 16S rRNA gene using next-generation sequencing. Participants were divided into four groups based on sex and lipid profile information. The results of one-way analysis of covariance, linear discriminant analysis effect size, and least absolute value reduction and selection operator logistic regression model indicated that several bacteria between men and women may be associated with DL. The LiNGAM showed a presumed causal relationship between different bacteria and lipid profiles in men and women. In men,
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