ArticleiScience2022
Hierarchical partner selection shapes rod-cone pathway specificity in the inner retina.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Stereotypical interciliary contacts in abioRxiv : the preprint server for biology · 2026Article
- Formation of sensory maps: New tools reveal novel insights into neural development.Current opinion in neurobiology · 2025Review
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- Ancient origin of the rod bipolar cell pathway in the vertebrate retina.Nature ecology & evolution · 2024Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Biased cell adhesion organizes a circuit for visual motion integration.bioRxiv : the preprint server for biology · 2023Article
- Article
- Regional variation in the organization and connectivity of the first synapse in the primate night vision pathway.iScience · 2023Article
- Ancient origin of the rod bipolar cell pathway in the vertebrate retina.Research square · 2023Article
- Ancient origin of the rod bipolar cell pathway in the vertebrate retina.bioRxiv : the preprint server for biology · 2023Article
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina.Frontiers in ophthalmology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Neurons form stereotyped microcircuits that underlie specific functions. In the vertebrate retina, the primary rod and cone pathways that convey dim and bright light signals, respectively, exhibit distinct wiring patterns. Rod and cone pathways are thought to be assembled separately during development. However, using correlative fluorescence imaging and serial electron microscopy, we show here that cross-pathway interactions are involved to achieve pathway-specific connectivity within the inner retina. We found that A17 amacrine cells, a rod pathway-specific cellular component, heavily bias their synaptogenesis with rod bipolar cells (RBCs) but increase their connectivity with cone bipolar cells (CBCs) when RBCs are largely ablated. This cross-pathway synaptic plasticity occurs during synaptogenesis and is triggered even on partial loss of RBCs. Thus, A17 cells adopt a hierarchical approach in selecting postsynaptic partners from functionally distinct pathways (RBC>CBC), in which contact and/or synaptogenesis with preferred partners (RBCs) influences connectivity with less-preferred partners (CBCs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.