Evidence map›Paper›PMID 36117966›Full record

ArticleFrontiers in medicine2022

The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort.

Cenk Babayigit, Nurdan Kokturk, Seval Kul, Pelin Duru Cetinkaya, Sibel Atis Nayci, Serap Argun Baris, Oguz Karcioglu, Pinar Aysert, Ilim Irmak, Aycan Akbas Yuksel and 58 more

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Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

68 authors.

Cenk BabayigitDepartment of Pulmonary Medicine, Faculty of Medicine, Mustafa Kemal University, Antakya, Turkey.
Nurdan KokturkDepartment of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey.
Seval KulDepartment of Biostatistics, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Pelin Duru CetinkayaDepartment of Pulmonary Medicine, Adana City Training and Research Hospital, University of Health Sciences, Adana, Turkey.
Sibel Atis NayciDepartment of Pulmonary Medicine, Faculty of Medicine, Mersin University, Yenişehir, Turkey.
Serap Argun BarisDepartment of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, İzmit, Turkey.
Oguz KarciogluDepartment of Pulmonary Medicine, Halil Şıvgın Cubuk State Hospital, Ankara, Turkey.
Pinar AysertDepartment of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ilim IrmakDepartment of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Aycan Akbas YukselDepartment of Pulmonary Medicine, Faculty of Medicine, Ufuk University, Ankara, Turkey.
Yonca SekibagDepartment of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Oya Baydar ToprakDepartment of Pulmonary Medicine, Faculty of Medicine, Çukurova University, Adana, Turkey.
Emel AzakDepartment of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Kocaeli University, İzmit, Turkey.
Sait MulamahmutogluDepartment of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Caglar CuhadarogluDepartment of Pulmonary Medicine, Faculty of Medicine, Altunizade Acibadem Hospital, Acibadem University, Istanbul, Turkey.
Aslihan DemirelDepartment of Infectious Disease, Kadıköy Florence Nightingale Hospital, Istanbul, Turkey.
Bugra KergetDepartment of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Burcu Baran KetenciogluDepartment of Pulmonary Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Hasan Selcuk OzgerDepartment of Infectious Disease, Faculty of Medicine, Gazi University, Ankara, Turkey.
Gulcihan OzkanDepartment of Pulmonary Medicine, Acibadem Maslak Hospital, Istanbul, Turkey.
Zeynep TureDepartment of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Begum ErganDepartment of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Vildan Avkan OguzDepartment of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Oguz KilincDepartment of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Merve ErcelikDepartment of Pulmonary Medicine, Faculty of Medicine, Düzce University, Düzce, Turkey.
Tansu Ulukavak CiftciDepartment of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey.
Ozlem AliciDepartment of Infectious Disease, Turkiye Gazetesi Private Hospital, Istanbul, Turkey.
Esra Nurlu TemelDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Ozlem AtaogluDepartment of Pulmonary Medicine, Faculty of Medicine, Düzce University, Düzce, Turkey.
Asena AydinDepartment of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey.
Dilek Cetiner BahcetepeDepartment of Pulmonary Medicine, Kestel State Hospital, Bursa, Turkey.
Yusuf Taha GulluDepartment of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Fusun FakiliDepartment of Pulmonary Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey.
Figen DeveciDepartment of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazıg˘, Turkey.
Neslihan KoseDepartment of Pulmonary Medicine, Bilecik Training and Research Hospital, Bilecik, Turkey.
Muge Meltem TorDepartment of Pulmonary Medicine, Faculty of Medicine, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Gulsah GunluogluDepartment of Pulmonary Medicine, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, University of Health Science, Istanbul, Turkey.
Sedat AltinDepartment of Pulmonary Medicine, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, University of Health Science, Istanbul, Turkey.
Teyfik TurgutDepartment of Pulmonary Medicine, Faculty of Medicine, Firat University, Elazıg˘, Turkey.
Tibel TunaDepartment of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Onder OzturkDepartment of Pulmonary Medicine, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Oner DikensoyDepartment of Pulmonary Medicine, Faculty of Medicine, Taksim, Acibadem University, Istanbul, Turkey.
Pinar Yildiz GulhanDepartment of Pulmonary Medicine, Faculty of Medicine, Düzce University, Düzce, Turkey.
Ilknur BasyigitDepartment of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, İzmit, Turkey.
Hasim BoyaciDepartment of Pulmonary Medicine, Faculty of Medicine, Kocaeli University, İzmit, Turkey.
Ipek Kivilcim OguzulgenDepartment of Pulmonary Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey.
Sermin BorekciDepartment of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Bilun GemiciogluDepartment of Pulmonary Disease, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Firat BayraktarDepartment of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Osman ElbekDepartment of Pulmonary Medicine, Kadıköy Florence Nightingale Hospital, Istanbul, Turkey.
Ismail HantaDepartment of Pulmonary Medicine, Faculty of Medicine, Çukurova University, Adana, Turkey.
Hacer Kuzu OkurDepartment of Pulmonary Medicine, Faculty of Medicine, Altunizade Acibadem Hospital, Acibadem University, Istanbul, Turkey.
Gulseren SagcanDepartment of Pulmonary Medicine, Faculty of Medicine, Altunizade Acibadem Hospital, Acibadem University, Istanbul, Turkey.
Oguz UzunDepartment of Pulmonary Medicine, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Metin AkgunDepartment of Pulmonary Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Goksel AltinisikDepartment of Pulmonary Medicine, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Berna DursunDepartment of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey.
Ebru Cakir EdisDepartment of Pulmonary Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.
Erkmen GulhanDepartment of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
Fusun Oner EyubogluDepartment of Pulmonary Medicine, School of Medicine, Başkent University, Ankara, Turkey.
Okkes GultekinDepartment of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Yavuz HavlucuDepartment of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Metin OzkanDepartment of Pulmonary Medicine, Ankara Memorial Hospital, Ankara, Turkey.
Aysin Sakar CoskunDepartment of Pulmonary Medicine, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Abdullah SayinerDepartment of Pulmonary Medicine, Faculty of Medicine, Ege University, Izmir, Turkey.
A Fuat KalyoncuDepartment of Pulmonary Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Oya ItilDepartment of Pulmonary Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Hasan BayramDepartment of Pulmonary Medicine, Koç University School of Medicine, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: Although several repurposed antiviral drugs have been used for the treatment of COVID-19, only a few such as remdesivir and molnupiravir have shown promising effects. The objectives of our study were to investigate the association of repurposed antiviral drugs with COVID-19 morbidity. Methods: Patients admitted to 26 different hospitals located in 16 different provinces between March 11-July 18, 2020, were enrolled. Case definition was based on WHO criteria. Patients were managed according to the guidelines by Scientific Board of Ministry of Health of Turkey. Primary outcomes were length of hospitalization, intensive care unit (ICU) requirement, and intubation. Results: We retrospectively evaluated 1,472 COVID-19 adult patients; 57.1% were men (mean age = 51.9 ± 17.7years). A total of 210 (14.3%) had severe pneumonia, 115 (7.8%) were admitted to ICUs, and 69 (4.7%) were intubated during hospitalization. The median (interquartile range) of duration of hospitalization, including ICU admission, was 7 (5-12) days. Favipiravir ( Conclusion: Our findings demonstrated that antiviral drugs including lopinavir, ritonavir, and favipiravir were associated with negative clinical outcomes such as increased risks for lengthy hospital stay, ICU admission, and invasive mechanical ventilation requirement. Therefore, repurposing such agents without proven clinical evidence might not be the best approach for COVID-19 treatment.

Indexed as

antiviral agentsCOVID-19 morbidityICU requirementinvasive mechanical ventilationlength of hospitalization

Identifiers

PMID36117966
PMCPMC9471091

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