Evidence map›Paper›PMID 36117382›Full record

ArticleAlcoholism, clinical and experimental research2022

The impact of prenatal alcohol and/or tobacco exposure on brain structure in a large sample of children from a South African birth cohort.

Andrew T Marshall, Stefanie C Bodison, Kristina A Uban, Shana Adise, Deborah Jonker, Weslin Charles, Kirsten A Donald, Eric Kan, Jonathan C Ipser, Letitia Butler-Kruger and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

Andrew T MarshallDepartment of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-0068-8138
Stefanie C BodisonDepartment of Occupational Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
Kristina A UbanDepartment of Public Health, University of California, Irvine, California, USA.
Shana AdiseDepartment of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Deborah JonkerDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Weslin CharlesDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Kirsten A DonaldDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Eric KanDepartment of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Jonathan C IpserNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Letitia Butler-KrugerDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Babette SteigelmannMaastricht University, Maastricht, The Netherlands.
Katherine L NarrDepartment of Neurology, UCLA Brain Mapping Center, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Shantanu H JoshiDepartment of Neurology, UCLA Brain Mapping Center, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Lucy T BrinkDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Hein J OdendaalDepartment of Obstetrics and Gynaecology, Stellenbosch University, Cape Town, South Africa.
Freda SchefflerNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Elizabeth R SowellDepartment of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
University of Cape Town · ZAUniversity of Southern California · USUniversity of California, Los Angeles · USMaastricht University · NLSouth African Medical Research Council · ZAStellenbosch University · ZAUniversity of California, Irvine · USUniversity of Florida · US

Funding

Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD045935 · NICHD · UNIVERSITY OF SOUTH DAKOTA · PI ELLIOTT, AMY J · 2003 to 2015
$16.9M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01AA016501 · NIAAA · STELLENBOSCH UNIVERSITY · PI ODENDAAL, HENDRIK JOHANNES · 2006 to 2015
$10.0M
Safe PASSage Study Administrative Supplement - Effects of Overnight Maternal SleeU01HD055154 · NICHD · DM-STAT, INC. · PI DUKES, KIMBERLY A. · 2006 to 2017
$9.7M
Prenatal Alcohol Sudden Infant Death Syndrome/StillbirthU01HD045991 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI KINNEY, HANNAH CHASE · 2003 to 2015
$8.4M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD055155 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIFER, WILLIAM P., MYERS, MICHAEL MORGAN · 2006 to 2015
$7.1M
Brain and Cognitive Development in the PASS Cohort: The Impact of PrenatalAlcohol ExposureR01AA025653 · NIAAA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI ELIZABETH R SOWELL · 2017 to 2026
$5.4M
Assessing Stable Characteristics of Endocrine Function Among Boys and Girls with Prenatal Alcohol Exposure as a Novel Clinical ToolK01AA026889 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI UBAN, KRISTINA ANDREA · 2018 to 2022
$894k
NIAAA NIH HHS K01 AA026889NIAAA NIH HHS R01 AA025653NIAAA NIH HHS U01 AA016501NICHD NIH HHS U01 HD045935NICHD NIH HHS U01 HD045991NICHD NIH HHS U01 HD055154NICHD NIH HHS U01 HD055155
6 · The paper itself

Abstract

backgroundNeuroimaging studies have emphasized the impact of prenatal alcohol exposure (PAE) on brain development, traditionally in heavily exposed participants. However, less is known about how naturally occurring community patterns of PAE (including light to moderate exposure) affect brain development, particularly in consideration of commonly occurring concurrent impacts of prenatal tobacco exposure (PTE).

methodsThree hundred thirty-two children (ages 8 to 12) living in South Africa's Cape Flats townships underwent structural magnetic resonance imaging. During pregnancy, their mothers reported alcohol and tobacco use, which was used to evaluate PAE and PTE effects on their children's brain structure. Analyses involved the main effects of PAE and PTE (and their interaction) and the effects of PAE and PTE quantity on cortical thickness, surface area, and volume.

resultsAfter false-discovery rate (FDR) correction, PAE was associated with thinner left parahippocampal cortices, while PTE was associated with smaller cortical surface area in the bilateral pericalcarine, left lateral orbitofrontal, right posterior cingulate, right rostral anterior cingulate, left caudal middle frontal, and right caudal anterior cingulate gyri. There were no PAE × PTE interactions nor any associations of PAE and PTE exposure on volumetrics that survived FDR correction.

conclusionPAE was associated with reduction in the structure of the medial temporal lobe, a brain region critical for learning and memory. PTE had stronger and broader associations, including with regions associated with executive function, reward processing, and emotional regulation, potentially reflecting continued postnatal exposure to tobacco (i.e., second-hand smoke exposure). These differential effects are discussed with respect to reduced PAE quantity in our exposed group versus prior studies within this geographical location, the deep poverty in which participants live, and the consequences of apartheid and racially and economically driven payment practices that contributed to heavy drinking in the region. Longer-term follow-up is needed to determine potential environmental and other moderators of the brain findings here and assess the extent to which they endure over time.

Indexed as

Prenatal Exposure Delayed EffectsBirth CohortBrainChildEthanolFemaleHumansPregnancySouth AfricaEthanolalcohol useneuroimagingprenatal exposure delayed effectsSouth Africatobacco use

Identifiers

PMID36117382
PMCPMC11334753
OpenAlexW4296295768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.