Evidence map›Paper›PMID 36117310›Full record

Trial reportPhysiological reports2022

Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial.

Katrine Brodersen, Maike Mose, Ulla Ramer Mikkelsen, Jens Otto Lunde Jørgensen, Michael Festersen Nielsen, Niels Møller, Anne-Marie Wegeberg, Christina Brock, Bolette Hartmann, Jens Juul Holst and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Katrine BrodersenDepartment of Surgery, Viborg Regional Hospital, Viborg, Denmark.ORCID 0000-0003-3388-1863
Maike MoseMedical/Steno Aarhus Research Laboratory, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Ulla Ramer MikkelsenArla Foods Ingredients Group P/S, Viby, Denmark.
Jens Otto Lunde JørgensenMedical/Steno Aarhus Research Laboratory, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-7408-1526
Michael Festersen NielsenDepartment of Surgery, Viborg Regional Hospital, Viborg, Denmark.
Niels MøllerMedical/Steno Aarhus Research Laboratory, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Anne-Marie WegebergMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
Christina BrockMech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
Bolette HartmannDepartment of Biomedical Sciences and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, København, Denmark.
Jens Juul HolstDepartment of Biomedical Sciences and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, København, Denmark.
Nikolaj RittigMedical/Steno Aarhus Research Laboratory, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Aarhus University Hospital · DKSteno Diabetes Centers · DKUniversity of Copenhagen · DKAalborg University Hospital · DKArla Foods (Denmark) · DKRegionshospitalet Viborg · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe systemic inflammation is associated with nausea, loss of appetite, and delayed gastric emptying, which increases hospitalization admission length and mortality rate. There is a lack of human controlled studies exploring gastric emptying rates and underlying mechanisms during inflammatory conditions. We aimed to investigate if systemic inflammation in young men delays gastro-intestinal transit times, lowers motility, and affects gastrointestinal hormone secretion. This substudy of a randomized crossover trial investigated eight healthy young men on two separate occasions; (I) following an overnight fast (healthy conditions/HC) and (II) fasting and bedrest combined with two lipopolysaccharide (LPS) injections of 1 ng kg

Indexed as

Gastrointestinal HormonesPeptide YYCross-Over StudiesGastrointestinal MotilityGlucagon-Like Peptide 1HumansInflammationLipopolysaccharidesMaleNauseaGastrointestinal HormonesGlucagon-Like Peptide 1LipopolysaccharidesPeptide YYendotoxemiagastrointestinal hormonesgastrointestinal motilitygastrointestinal transit timesinflammationwireless motility capsule

Identifiers

PMID36117310
PMCPMC9483438
OpenAlexW4296331174

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.