Evidence map›Paper›PMID 36117166›Full record

ArticleWorld journal of surgical oncology2022

The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt.

Dina Sweed, Enas Sweed, Inas Moaz, Asmaa Mosbeh, Yahya Fayed, Sara Mohamed Abd Elhamed, Eman Sweed, Mahmoud Macshut, Shimaa Abdelsattar, Shimaa Kilany and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05047146 (The Clinicopathological and Prognostic Factors of Hepatocellular Carcinoma; 10 Years' Tertiary Center Experience in Egypt), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05047146 completednot on this map

The Clinicopathological and Prognostic Factors of Hepatocellular Carcinoma; 10 Years' Tertiary Center Experience in Egypt

TypeobservationalSponsorSadat City UniversityRan2021 to 2022Enrolled530ConditionsHepatocellular CarcinomaArmsMorphological classifications of HCC
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Dina SweedPathology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.ORCID https://orcid.org/0000-0001-6483-5056
Enas SweedRadiology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Inas MoazEpidemiology, and Preventive Medicine Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Asmaa MosbehPathology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.ORCID https://orcid.org/0000-0001-6951-4323
Yahya FayedHepatopancreatobiliary Surgery Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Sara Mohamed Abd ElhamedPathology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Eman SweedClinical Pharmacology Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Menoufia, Egypt. eman.sweed@med.menofia.edu.eg.ORCID https://orcid.org/0000-0003-3689-2648
Mahmoud MacshutHepatopancreatobiliary Surgery Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Shimaa AbdelsattarClinical Biochemistry and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.ORCID https://orcid.org/0000-0002-3993-5378
Shimaa KilanyHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Sara A SaiedClinical Pathology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Reda BadrHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Mahmoud S AbdallahClinical Pharmacy, Faculty of Pharmacy, University of Sadat City, Sadat City, Menoufia, Egypt.ORCID https://orcid.org/0000-0002-3237-1792
Nermine EhsanPathology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt.
Menoufia University · EGBenha University · EGUniversity of Sadat City · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) remains a major health problem despite the emergence of several preventive and therapeutic modalities. HCC has heterogeneous and wide morpho-molecular patterns, resulting in unique clinical and prognostic criteria. Therefore, we aimed to study the clinical and pathological criteria of HCC to update the morpho-molecular classifications and provide a guide to the diagnosis of this disease.

methodsFive hundred thirty pathologically analyzed HCC cases were included in this study. The clinical and survival data of these cases were collected.

resultsHepatitis C virus is still the dominant cause of HCC in Egypt. Post-direct-acting antiviral agent HCC showed an aggressive course compared to interferon-related HCC. Old age, male gender, elevated alpha-fetoprotein level, tumor size, and background liver were important prognostic parameters. Special HCC variants have characteristic clinical, laboratory, radiological, prognostic, and survival data. Tumor-infiltrating lymphocytes rather than neutrophil-rich HCC have an excellent prognosis.

conclusionsHCC is a heterogenous tumor with diverse clinical, pathological, and prognostic parameters. Incorporating the clinicopathological profile per specific subtype is essential in the treatment decision of patients with HCC.

trial registrationThis was a retrospective study that included 530 HCC cases eligible for analysis. The cases were obtained from the archives of the Pathology Department, during the period between January 2010 and December 2019. Clinical and survival data were collected from the patients' medical records after approval by the institutional review board (IRB No. 246/2021) of Liver National Institute, Menoufia University. The research followed the guidelines outlined in the Declaration of Helsinki and registered on ClinicalTrials.gov (NCT05047146).

Indexed as

Carcinoma, HepatocellularHepatitis C, ChronicLiver Neoplasmsalpha-FetoproteinsAntiviral AgentsEgyptHumansInterferonsMalePrognosisRetrospective Studiesalpha-FetoproteinsAntiviral AgentsInterferonsDAAsHepatitis C virusHepatocellular carcinomaPathological subtypesprognosis

Identifiers

PMID36117166
PMCPMC9484175
OpenAlexW4296327792

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.