Evidence map›Paper›PMID 36116835›Full record

ReviewInfectious disease clinics of North America2022

Lyme Arthritis.

Sheila L Arvikar, Allen C Steere

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Transosseous Endoscopy for Bone Grafting of Proximal Tibial Bone Cysts.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Article
  6. Review
  7. Lyme borreliosis.Nature reviews. Disease primers · 2026
    Review
  8. Article
  9. The Lyme Disease Vaccine Paradox.Journal of clinical medicine · 2026
    Article
  10. Article
  11. Article
  12. [Reactive arthritis].Zeitschrift fur Rheumatologie · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Lyme Arthritis: A 50-Year Journey.The Journal of infectious diseases · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sheila L ArvikarCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, CNY149 Room 8301, 149 13th Street, Charlestown, MA 02129, USA. Electronic address: sarvikar@mgh.harvard.edu.
Allen C SteereCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, CNY149 Room 8301, 149 13th Street, Charlestown, MA 02129, USA.

Funding

Borrelia burgdorferi-Induced Autoimmunity in Lyme DiseaseR01AI101175 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STEERE, ALLEN C · 2013 to 2021
$3.6M
Cellular and humoral immunity in Lyme arthritisR01AI144365 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI STEERE, ALLEN C · 2019 to 2023
$2.9M
NIAID NIH HHS R01 AI101175NIAID NIH HHS R01 AI144365
6 · The paper itself

Abstract

Arthritis is the most common late manifestation of Borrelia burgdorferi infection in the United States, usually beginning months after the tick bite. In most patients with Lyme arthritis (LA) today, arthritis is the presenting manifestation of the disease. Patients have swelling and pain in one or a few large joints, especially the knee. Serologic testing is the mainstay of diagnosis. Responses to antibiotic treatment are generally excellent, although a small percentage of patients have persistent, postinfectious synovitis after 2 to 3 months of oral and IV antibiotics, which respond to anti-inflammatory therapies. Herein we review the clinical presentation, diagnosis, and management of LA.

Indexed as

ArthritisLyme DiseaseAnti-Bacterial AgentsAnti-Inflammatory AgentsHumansAnti-Bacterial AgentsAnti-Inflammatory AgentsBorrelia burgdorferiInflammatory arthritisLyme arthritisLyme diseasePostantibiotic arthritisPostinfectious arthritis

Identifiers

PMID36116835
PMCPMC9533683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.