Evidence map›Paper›PMID 36116158›Full record

ArticleRedox biology2022

Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms.

Yixuan Zhang, Kin Lung Siu, Qiang Li, Kimberly Howard-Quijano, Jennifer Scovotti, Aman Mahajan, Hua Cai

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yixuan ZhangDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, California, 90095, USA.
Kin Lung SiuDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, California, 90095, USA.
Qiang LiDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, California, 90095, USA.
Kimberly Howard-QuijanoDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pennsylvania, 15260, USA.
Jennifer ScovottiDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, California, 90095, USA.
Aman MahajanDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pennsylvania, 15260, USA.
Hua CaiDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, California, 90095, USA. Electronic address: hcai@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

Angiotensin II Uncoupling of Enos in HypertensionR01HL077440 · NHLBI · UNIVERSITY OF CHICAGO · PI CAI, HUA LINDA · 2005 to 2019
$4.8M
NOXs, eNOS Uncoupling and Diabetic AtherogenesisR01HL088975 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2010 to 2019
$4.5M
Targeting NOX4-dependent mitochondrial dysfunction, autophagy and defective calcium handling in AFR01HL162407 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, GOLDHABER, JOSHUA I · 2022 to 2025
$2.8M
Phenotypes and mechanisms of pulmonary hypertension-driven cognitive impairment and Alzheimer's diseaseR01HL154754 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, MAKINO, AYAKO · 2020 to 2023
$2.5M
Netrin-1 and Netrin-1 Preconditioned EPCs in Vascular ProtectionR01HL142951 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA · 2020 to 2023
$2.0M
NHLBI NIH HHS R01 HL077440NHLBI NIH HHS R01 HL088975NHLBI NIH HHS R01 HL142951NHLBI NIH HHS R01 HL154754NHLBI NIH HHS R01 HL162407
6 · The paper itself

Abstract

We have previously shown that circulating levels of tetrahydrobiopterin (H

Indexed as

Aortic Aneurysm, AbdominalAortic Aneurysm, ThoracicHydroxymethylglutaryl-CoA Reductase InhibitorsAnimalsBiomarkersBiopterinsHumansBiomarkersBiopterinsHydroxymethylglutaryl-CoA Reductase InhibitorssapropterinAbdominal aortic aneurysm (AAA)Aortic aneurysmBiomarkerDiagnosiseNOS uncouplingHuman patientsMonitoringPredictionTetrahydrobiopterin (H(4)B)Thoracic aortic aneurysm (TAA)

Identifiers

PMID36116158
PMCPMC9486112
OpenAlexW4292266639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.