Evidence map›Paper›PMID 36116092›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2023

The prognostic significance of bundle branch block in acute heart failure: a systematic review and meta-analysis.

Oriol Aguiló, Xavier Castells, Òscar Miró, Christian Mueller, Ovidiu Chioncel, Joan Carles Trullàs

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Short-term outcomes of acute heart failure hospitalizations in Ethiopia: A multicenter prospective study.American heart journal plus : cardiology research and practice · 2025
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  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Oriol AguilóEmergency Department, Hospital d'Olot i Comarcal de la Garrotxa, Girona, Catalonia, Spain.ORCID http://orcid.org/0000-0001-8695-8508
Xavier CastellsTransLab Research Group, Department of Medical Sciences, Universitat de Girona, Girona, Catalonia, Spain.
Òscar MiróEmergency Department, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain.
Christian MuellerDepartment of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
Ovidiu ChioncelEmergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu' and University of Medicine Carol Davila, Bucharest, Romania.
Joan Carles TrullàsTissue Repair and Regeneration Laboratory (TR2Lab), Universitat de Vic-Universitat Central de Catalunya, Vic, Barcelona, Catalonia, Spain. jctv5153@comg.cat.
Universitat de Vic - Universitat Central de Catalunya · ESCarol Davila University of Medicine and Pharmacy · ROHospital Clínic de Barcelona · ESUniversitat de Girona · ESUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of this study was to conduct a meta-analysis of prospective studies assessing the relationship between bundle branch block (BBB) or wide QRS and risk of all-cause mortality in patients with acute heart failure (AHF). METHODS AND

resultsWe searched the PubMed, Scopus and Web of Science database from inception to February 2022 to identify single centre or multicentre studies including a minimum of 400 patients and assessing the association between BBB or wide QRS and mortality in patients with AHF. Study-specific hazard ratio (HR) estimates were combined using a random-effects meta-analysis. Two meta-analyses were performed: (1) grouping by conduction disturbance and follow-up length and, (2) using the results from the longest follow-up for each study and grouping by the type of BBB. The meta-analysis included 21 publications with a total of 116,928 patients. Wide QRS (considering right (RBBB) and left (LBBB) altogether) was associated with a significant increment in the risk of all-cause mortality (pooled adjusted HR 1.112, 95% CI 1.065-1.160). The increased risk of death was also present when LBBB (HR 1.121, 95% CI 1.042-1.207) and RBBB (HR 1.187, 95% CI 1.045-1.348) were considered individually. There was no difference in risk between LBBB and RBBB (P for interaction = 0.533). Other outcomes including sudden death, rehospitalization and a combination of cardiovascular death or rehospitalization were also increased in patients with BBB or wide QRS.

conclusionsThis meta-analysis suggests a modest increase in the risk of all-cause mortality among patients with AHF and BBB or wide QRS, irrespective of the type of BBB.

Indexed as

Bundle-Branch BlockHeart FailureCardiac Conduction System DiseaseElectrocardiographyHeart BlockHumansPrognosisProspective StudiesRisk FactorsBundle-branch blockHeart failureLeft bundle branch blockMortalityPrognosisRight bundle branch block

Identifiers

PMID36116092
OpenAlexW4296248385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.