ArticleNature communications2022
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
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39 citing papers in PubMed, 61 citations in OpenAlex.
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- Metabolic-inflammatory memory: the common pathological basis and therapeutic targets of metabolic syndrome.Reviews in endocrine & metabolic disorders · 2026Review
- Immune Mechanisms of Heart Valve Development, Homeostasis, and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Extracellular matrix remodeling in calcific aortic valve disease: Localized enrichment of type III collagen and LTBP-4.Matrix biology plus · 2026Article
- Cluster of Differentiation 36-Mediated Inflammation and Lipid Metabolism in Cardiovascular Diseases: From Mechanisms to Novel Therapies.Antioxidants (Basel, Switzerland) · 2026Review
- Integrated bioinformatic analysis and experiments reveal EFEMP1 as a novel aging-related signature gene in calcific aortic valve disease.Scientific reports · 2026Article
- Single-nucleus and machine-learning integration identifies HLA-DRA and FTL as immune-metabolic axes and traditional Chinese medicine-targetable hubs in calcific aortic valve disease.Journal of computer-aided molecular design · 2026Article
- Hypoxia-inducible factors link inflammation and lipid metabolism in atherosclerotic macrophages.Frontiers in cardiovascular medicine · 2026Review
- Osteopontin-expressing valvular interstitial cell subpopulation as a driver of extracellular matrix remodeling in aortic valve disease.Frontiers in cardiovascular medicine · 2026Article
- Article
- Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.Nature genetics · 2026Article
- The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Early Supplementation with Branched-Chain Amino Acids Ameliorates Lipid Retention in Aortic Valves of ApoE-Knockout Mice.International journal of molecular sciences · 2025Article
- Decoding heart failure subtypes with neural networks via differential explanation analysis.Briefings in bioinformatics · 2025Article
- Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification.Cardiovascular research · 2025Article
- Imaging lipid deposition induced by local hypoxia in degenerative aortic valve disease using a twisted intramolecular charge transfer (TICT)-based lipid droplet-targeting probe.Mikrochimica acta · 2025Article
- Immune Cell Dynamics in Cardiac Diseases: Insights From Single-Cell Sequencing.Journal of cellular and molecular medicine · 2025Review
- Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves.JACC. Basic to translational science · 2025Article
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Authors and funding
30 authors at 10 institutions in 2 countries.
Seung Hyun Lee *Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.ORCID 0000-0002-4876-0477
Nayoung Kim *Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.ORCID 0000-0003-3202-750X
Minkyu Kim *Department of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.ORCID 0000-0001-5482-744X
Sang-Ho WooDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
Inhee HanDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Jisu ParkDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Kyeongdae KimDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Kyu Seong ParkDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Kibyeong KimDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Dahee ShimDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Sang-Eun ParkDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Jing Yu ZhangDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.
Du-Min GoDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
Dae-Yong KimDepartment of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Republic of Korea.
Won Kee YoonLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, Republic of Korea.
Seung-Pyo LeeCardiovascular Center and Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.ORCID 0000-0002-5502-3977
Jongsuk ChungSamsung Genome Institute, Samsung Medical Center, Seoul, 06351, Republic of Korea.ORCID 0000-0002-4423-5122
Ki-Wook KimDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, IL, 60612, USA.ORCID 0000-0002-7207-4389
Jung Hwan ParkDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, 04763, Republic of Korea.
Seung Hyun LeeDivision of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Sak LeeDivision of Cardiovascular Surgery, Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Soo-Jin AnnIntegrative Research Center for Cerebrovascular and Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Sang-Hak LeeDivision of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Hyo-Suk AhnDivision of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, 11765, Republic of Korea.
Seong Cheol JeongDepartment of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, 11765, Republic of Korea.
Tae Kyeong KimHeart-Immune-Brain Network Research Center, Department of Life Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
Goo Taeg OhHeart-Immune-Brain Network Research Center, Department of Life Science, Ewha Womans University, Seoul, 03760, Republic of Korea.ORCID 0000-0002-1104-1698
Woong-Yang ParkSamsung Genome Institute, Samsung Medical Center, Seoul, 06351, Republic of Korea.ORCID 0000-0003-4234-0380
Hae-Ock LeeDepartment of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. haeocklee@catholic.ac.kr.ORCID 0000-0001-5123-0322
Jae-Hoon ChoiDepartment of Life Science, College of Natural Sciences, Hanyang Institute of Bioscience and Biotechnology, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea. jchoi75@hanyang.ac.kr.ORCID 0000-0002-5265-3463
Hanyang University · KRYonsei University · KRIllinois College · USSeoul National University · KRCatholic University of Korea · KREwha Womans University · KRThe Catholic University of Korea Uijeongbu St. Mary's Hospital · KRKorea Research Institute of Bioscience and Biotechnology · KRSamsung Medical Center · KRSamsung (South Korea) · KR
Funding
Role of membrane-associated macrophages in health and inflammationR01DK126753 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KIM, KIWOOK · 2021 to 2025
$2.1MNIDDK NIH HHS R01 DK126753
Abstract
Valvular inflammation triggered by hyperlipidemia has been considered as an important initial process of aortic valve disease; however, cellular and molecular evidence remains unclear. Here, we assess the relationship between plasma lipids and valvular inflammation, and identify association of low-density lipoprotein with increased valvular lipid and macrophage accumulation. Single-cell RNA sequencing analysis reveals the cellular heterogeneity of leukocytes, valvular interstitial cells, and valvular endothelial cells, and their phenotypic changes during hyperlipidemia leading to recruitment of monocyte-derived MHC-II
Indexed as
Aortic Valve StenosisCalcinosisHyperlipidemiasAnimalsAortic ValveCells, CulturedEndothelial CellsHumansImmunomodulationInflammationLipoproteins, LDLMicePioglitazonePPAR gammaTranscriptomeLipoproteins, LDLPioglitazonePPAR gamma
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