Observational studyBritish journal of anaesthesia2023
Pulmonary artery wave reflection and right ventricular function after lung resection.
Observational study in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01892800 (The Pulmonary Vascular / Right Ventricular Response to Lung Resection), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Pulmonary Vascular / Right Ventricular Response to Lung Resection
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- The lung-muscle metabolic axis: a proposed mechanism for post-resection systemic frailty.Surgery today · 2026Review
- Perioperative NT-proBNP in Lung Cancer Surgery: A Narrative Review of Mechanisms, Predictive Value, and Clinical Implications.Journal of clinical medicine · 2026Review
- Surgical extent as a determinant of systemic reserve after lung resection: Why spirometric recovery does not capture the true physiological cost.JTCVS open · 2026Article
- Evaluation of right ventricle indices changes after pneumonectomy and lobectomy surgery by ERNV scan.Journal of cardiothoracic surgery · 2026Article
- Pulmonary hypertension associated with nonparenchymal restrictive lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Wave intensity analysis with exercise identifies impairments in pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2025Article
- Lobectomy Induces Exercise-Induced Pulmonary Hypertension and Effort Intolerance Compared With Sublobar Resection.JTO clinical and research reports · 2025Article
- Left ventricular stroke volume decreases due to surgical procedures of anatomical lung resection.Thoracic cancer · 2024Article
- Epidemiology of perioperative RV dysfunction: risk factors, incidence, and clinical implications.Perioperative medicine (London, England) · 2024Review
- Characterization of pulmonary arterial stiffness using cardiac MRI.The international journal of cardiovascular imaging · 2024Review
- Risk factors and prognostic analysis of right ventricular dysfunction after lung resection for NSCLC.Frontiers in oncology · 2024Article
- Relationship between pulmonary blood flow and volume following lung resection using dynamic perfusion digital radiography.Journal of thoracic disease · 2023Article
- Article
- Perioperative cardiovascular pathophysiology in patients undergoing lung resection surgery: a narrative review.British journal of anaesthesia · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung resection has been shown to impair right ventricular function. Although conventional measures of afterload do not change, surgical ligation of a pulmonary artery branch, as occurs during lobectomy, can create a unilateral proximal reflection site, increasing wave reflection (pulsatile component of afterload) and diverting blood flow through the contralateral pulmonary artery. We present a cardiovascular magnetic resonance imaging (MRI) observational cohort study of changes in wave reflection and right ventricular function after lung resection.
methodsTwenty-seven patients scheduled for open lobectomy for suspected lung cancer underwent cardiovascular MRI preoperatively, on postoperative Day 2, and at 2 months. Wave reflection was assessed in the left and right pulmonary arteries (operative and non-operative, as appropriate) by wave intensity analysis and calculation of wave reflection index. Pulmonary artery blood flow distribution was calculated as percentage of total blood flow travelling in the non-operative pulmonary artery. Right ventricular function was assessed by ejection fraction and strain analysis.
resultsOperative pulmonary artery wave reflection increased from 4.3 (2.1-8.8) % preoperatively to 9.5 (4.9-14.9) % on postoperative Day 2 and 8.0 (2.3-11.7) % at 2 months (P<0.001) with an associated redistribution of blood flow towards the nonoperative pulmonary artery (r>0.523; P<0.010). On postoperative Day 2, impaired right ventricular ejection fraction was associated with increased operative pulmonary artery wave reflection (r=-0.480; P=0.028) and pulmonary artery blood flow redistribution (r=-0.545; P=0.011). At 2 months, impaired right ventricular ejection fraction and right ventricular strain were associated with pulmonary artery blood flow redistribution (r=-0.634, P=0.002; r=0.540, P=0.017).
conclusionsPulsatile afterload increased after lung resection. The unilateral increase in operative pulmonary artery wave reflection resulted in redistribution of blood flow through the nonoperative pulmonary artery and was associated with right ventricular dysfunction. CLINICAL
trial registrationNCT01892800.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.