Evidence map›Paper›PMID 36115699›Full record

ArticleDental materials : official publication of the Academy of Dental Materials2022

Novel antibacterial low-shrinkage-stress resin-based cement.

Rashed AlSahafi, Xiaohong Wang, Heba Mitwalli, Abdullah Alhussein, Abdulrahman A Balhaddad, Mary Anne S Melo, Thomas W Oates, Jirun Sun, H K Xu, Michael D Weir

Abstract read
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In one paragraph

Article in Dental materials : official publication of the Academy of Dental Materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Beyond antibiotics: advances in photothermal strategies for oral infections.Frontiers in bioengineering and biotechnology · 2025
    Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Rashed AlSahafiPhD Program in Dental Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Restorative Dental Sciences, Umm Al-Qura University, College of Dentistry, Makkah 24211, Saudi Arabia.
Xiaohong WangAmerican Dental Association Science and Research Institute, LLC., Gaithersburg, MD 20899, USA.
Heba MitwalliDepartment of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh 11451, Saudi Arabia.
Abdullah AlhusseinPhD Program in Dental Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh 11451, Saudi Arabia.
Abdulrahman A BalhaddadDepartment of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O.Box 1982, Dammam 31441, Saudi Arabia.
Mary Anne S MeloDivision of Operative Dentistry, Department of General Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Biomaterials & Tissue Engineering Division, Dept. of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USA.
Thomas W OatesBiomaterials & Tissue Engineering Division, Dept. of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USA.
Jirun SunThe Forsyth Institute, Harvard School of Dental Medicine Affiliate, Cambridge, MA 02142, USA. Electronic address: jsun@forsyth.org.
H K XuBiomaterials & Tissue Engineering Division, Dept. of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: HXu2@umaryland.edu.
Michael D WeirBiomaterials & Tissue Engineering Division, Dept. of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USA. Electronic address: Michael.weir@umaryland.edu.
University of Maryland, Baltimore · USKing Saud University · SAAmerican Dental Association · USImam Abdulrahman Bin Faisal University · SAUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

Funding

Novel Dental Resin Composites with Improved Service LifeU01DE023752 · NIDCR · AMERICAN DENTAL ASSOCIATION FOUNDATION · PI SUN, JIRUN · 2013 to 2017
$2.2M
NIDCR NIH HHS U01 DE023752
6 · The paper itself

Abstract

objectiveA low-shrinkage-stress resin-based cement with antibacterial properties could be beneficial to create a cement with lower stress at the tooth-restoration interface, which could help to enhance the longevity of the fixed dental restoration by reducing microleakage and recurrent caries. To date, there has been no report on the development of a low-shrinkage-stress and bio-interactive cement. Therefore, the objectives of this study were to develop a novel low-shrinkage-stress resin-based cement containing dimethylaminohexadecyl methacrylate (DMAHDM) and investigate the mechanical and antibacterial properties for the first time.

methodsThe monomers urethane dimethacrylate (UDMA) and triethylene glycol divinylbenzyl ether (TEG-DVBE) were combined and denoted as UV resin. Three cements were fabricated: (1) UV+ 0%DMAHDM (experimental control); (2) UV+ 3%DMAHDM, (3) UV+ %5DMAHDM. RelyX Ultimate cement was used as commercial control. Mechanical properties and Streptococcus mutans (S. mutans) biofilms growth on cement were evaluated.

resultsThe novel bio-interactive cement demonstrated excellent antibacterial and mechanical properties. Compared to commercial and experimental controls, adding DMAHDM into the UV cement significantly reduced colony forming unit (CFU) counts by approximately 7 orders of magnitude, metabolic activities from 0.29 ± 0.03 A

conclusionsThe new antibacterial low-shrinkage-stress resin-based cement provides strong antibacterial action and maintains excellent mechanical properties with reduced polymerization shrinkage stress. CLINICAL SIGNIFICANCE: A low-shrinkage-stress resin-based cement containing DMAHDM was developed with potent antibacterial effects and promising mechanical properties. This cement may potentially enhance the longevity of fixed dental restoration such as a dental crown, inlay, onlay, and veneers through its excellent mechanical properties, low shrinkage stress, and strong antibacterial properties.

Indexed as

MethacrylatesResin CementsAnti-Bacterial AgentsBiofilmsDental CementsDental MaterialsEthersLactic AcidMethylaminesAnti-Bacterial AgentsDental CementsDental Materialsdimethylaminohexadecyl methacrylateEthersLactic AcidMethacrylatesMethylaminesResin CementsAntibacterialBio-interactiveCariesLow polymerization stressOral biofilmsResin cement

Identifiers

PMID36115699
PMCPMC13631836
OpenAlexW4296124985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.