Evidence map›Paper›PMID 36115623›Full record

ArticleThe Journal of pediatrics2023

Lack of Age-Appropriate Reference Intervals Causing Potentially Missed Alerts in Clinical Reports of Dyslipidemia.

Cecilia Sena, Michael Ohene-Adjei, Shuliang Deng, Nandan Patibandla, Benjamin May, Sarah D de Ferranti, Thomas J Starc, Vidhu V Thaker

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Cecilia SenaDepartment of Pediatrics, Columbia University Medical Center, New York, NY.
Michael Ohene-AdjeiDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
Shuliang DengDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
Nandan PatibandlaBoston Children's Hospital, Boston, MA.
Benjamin MayHerbert Irving Cancer Center, Columbia University Medical Center, New York, NY.
Sarah D de FerrantiDepartment of Cardiology, Boston Children's Hospital, Boston, MA.
Thomas J StarcDepartment of Pediatrics, Columbia University Medical Center, New York, NY.
Vidhu V ThakerDepartment of Pediatrics, Columbia University Medical Center, New York, NY. Electronic address: vvt2114@cumc.columbia.edu.
Columbia University Irving Medical Center · USBeth Israel Deaconess Medical Center · USBoston Children's Hospital · USBoston Children's Museum · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · US

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Genetics of Early Childhood Obesity and its Clinical ImplicationsK23DK110539 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI THAKER, VIDHU V. · 2016 to 2021
$996k
NCATS NIH HHS UL1 TR001873NIDDK NIH HHS K23 DK110539
6 · The paper itself

Abstract

This study shows that only 12.5% of laboratory reports (2/16) included age-appropriate pediatric reference ranges for all lipid and lipoproteins. The use of erroneous reference range(s) could lead to missed alerts of dyslipidemia in up to 97.3% (total cholesterol), 93.6% (high-density lipoprotein cholesterol), 94.8% (low-density lipoprotein cholesterol), and 87.8% (triglycerides) of youth in the population-based National Health and Nutrition Examination Survey cohort. These findings highlight the potential missed opportunities for reinforcing lifestyle counseling for dyslipidemia in addition to obesity in youth.

Indexed as

DyslipidemiasAdolescentChildCholesterol, HDLCholesterol, LDLHumansNutrition SurveysTriglyceridesCholesterol, HDLCholesterol, LDLTriglycerides

Identifiers

PMID36115623
PMCPMC10230545
OpenAlexW4295921735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.