Evidence map›Paper›PMID 36115544›Full record

ArticleBrain, behavior, and immunity2022

Dorsal root ganglia CX3CR1 expressing monocytes/macrophages contribute to arthritis pain.

Silvia Oggero, Chiara Cecconello, Rita Silva, Lynda Zeboudj, George Sideris-Lampretsas, Mauro Perretti, Marzia Malcangio

Open access · hybridAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. TRPM2 is a direct pain transducer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Cannabinoid CBBritish journal of pharmacology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. A perspective: neuraxial therapeutics in pain management: now and future.Frontiers in pain research (Lausanne, Switzerland) · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Silvia OggeroWolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK.
Chiara CecconelloThe William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
Rita SilvaWolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK.
Lynda ZeboudjWolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK.
George Sideris-LampretsasWolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK.
Mauro PerrettiThe William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK; Centre for Inflammation and Therapeutic Innovation, Queen Mary University of London, London, UK.
Marzia MalcangioWolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK. Electronic address: marzia.malcangio@kcl.ac.uk.
King's College London · GBQueen Mary University of London · GBWilliam Harvey Research Institute · GB

Funding

Department of HealthVersus Arthritis 21961
6 · The paper itself

Abstract

Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model recapitulates both association and dissociation between pain and joint inflammation in RA. Furthermore, this model features monocyte/macrophage infiltration in joints and lumbar dorsal root ganglia (DRG), where these immune cells are close to nociceptive neurons. We focussed on CX

Indexed as

Arthritis, RheumatoidChemokine CX3CL1Calcitonin Gene-Related PeptideCX3C Chemokine Receptor 1Ganglia, SpinalHumansInterleukin-6LigandsMacrophagesMonocytesPainCalcitonin Gene-Related PeptideChemokine CX3CL1CX3C Chemokine Receptor 1CX3CR1 protein, humanInterleukin-6LigandsArthritisCGRPFractalkineMacrophagesMonocytesPain

Identifiers

PMID36115544
PMCPMC10166715
OpenAlexW4295762986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.