Trial reportPsychiatry and clinical neurosciences2022
The preventive effect of internet-based cognitive behavioral therapy for prevention of depression during pregnancy and in the postpartum period (iPDP): a large scale randomized controlled trial.
Trial report in Psychiatry and clinical neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effect of prenatal online interventions on postpartum depressive symptoms and well-being: a systematic review and meta-analysis.Archives of women's mental health · 2025Pooled it
- Proactive approaches to preventing postpartum depression in non-depressive pregnant women: a comprehensive scoping review.Frontiers in global women's health · 2025Pooled it
- Investigating the Effectiveness of Technology-Based Distal Interventions for Postpartum Depression and Anxiety: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2024Pooled it
- The effect of digital health interventions on postpartum depression or anxiety: a systematic review and meta-analysis of randomized controlled trials.American journal of obstetrics and gynecology · 2024Pooled it
- App-based interventions for the prevention of postpartum depression: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Long-term effects of mHealth consultation services on postpartum depressive symptoms and the mediating role of loneliness: A follow-up study of a randomized controlled trial.Psychological medicine · 2025Trial
- Internet-Based Cognitive Behavioral Therapy for Preventing Postpartum Depressive Symptoms Among Pregnant Individuals With Depression: Multicenter Randomized Controlled Trial in China.Journal of medical Internet research · 2025Trial
- Restless legs syndrome without insomnia and antenatal depressive symptoms.BMC pregnancy and childbirth · 2025Trial
- Differences in Center for Epidemiologic Studies Depression Scale, Generalized Anxiety Disorder-7 and Kessler Screening Scale for Psychological Distress Scores between Smartphone Version versus Paper Version Administration: Evidence of Equivalence.International journal of environmental research and public health · 2023Trial
- Preventing Postpartum Depression in the Early Postpartum Period Using an App-Based Cognitive Behavioral Therapy Program: A Pilot Randomized Controlled Study.International journal of environmental research and public health · 2022Trial
- Time-varying restless legs syndrome and risk of incident perinatal depression.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Advances in Perinatal Depression: A Focus on Screening and Treatment.Journal of clinical medicine · 2026Review
- Intimate partner violence and the risk of incident perinatal depression: A prospective study during pregnancy and the postpartum period.Psychiatry and clinical neurosciences · 2026Article
- Application of internet-based cognitive behavioral therapy for negative emotions in pregnant women: a narrative review.Frontiers in psychiatry · 2026Review
- Effectiveness of Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms During Pregnancy by Using Real-World Data: Retrospective Cohort Study.JMIR mHealth and uHealth · 2025Article
- Antenatal and postpartum depression among women who conceived after pregnancy loss: a longitudinal study.Archives of women's mental health · 2025Article
- Cost-utility analysis of screening and cognitive behavioral therapy compared to usual care for postpartum depression.BMC psychiatry · 2025Article
- Article
- Reducing the risk of perinatal depression using an app-based cognitive behavioral therapy program: protocol of a randomized controlled trial.Frontiers in psychiatry · 2025Article
- Recognizing distinctiveness of perinatal depression from depression in non-perinatal population: an urgent call for action.Frontiers in public health · 2025Article
Corrections and comments
- Erratum issuedErratum.2023
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrevention of perinatal depression beginning from the antenatal period is essential. Therefore, this study aimed to investigate the effectiveness of recently developed internet-delivered cognitive behavioral therapy (iCBT) for preventing the onset of a major depressive episode (MDE) in the third trimester and at 3 months postpartum.
methodsThis is a two-arm, parallel-group, general-information controlled, randomized controlled trial. Participants were 5017 pregnant women at 16-20 weeks' gestation without MDE at baseline. They were randomly assigned to an iCBT (intervention; n = 2509) or general-information (control; n = 2508) group, stratified by psychological distress at baseline. The primary outcomes were the numbers of new MDE onsets, measured using the World Health Organization Composite International Diagnostic Interview 3.0, at 32 weeks' gestation and at 3 months postpartum.
resultsNew MDE onset was reported by 59 participants (2.35%) in the intervention group and 73 (2.91%) in the control group during follow-up. Compared with the control group, the hazard ratio (HR) of MDE in the intervention group was 0.85 (95% CI 0.61-1.20), which was not significantly different. Among participants who scored between 5 and 8 on K6 at baseline, 10 (1.37%) in the intervention group reported new onset of MDE, compared with 28 (3.81%) in the control group, and the HR of MDE was 0.38 (95%CI 0.19-0.79).
conclusionsNo intervention effect was found for iCBT in preventing new onset of perinatal MDE. iCBT might prevent perinatal depression only among pregnant women with subthreshold depressive symptoms.
trial registrationUMIN000038190.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.